Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes

• Published in: PloS one 2018-04, Vol.13 (4), p.e0194750-e0194750
• Main Authors: Moser, Othmar, Eckstein, Max L, McCarthy, Olivia, Deere, Rachel, Bain, Stephen C, Haahr, Hanne L, Zijlstra, Eric, Heise, Tim, Bracken, Richard M
• Format: Article
• Language: English
• Subjects: Aerobic exercises; Anthropometry; Biology and life sciences; Body measurements; Cardiovascular disease; Clinical medicine; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Engineering schools; Exercise; Exhaustion; Females; Glucose; Heart failure; Heart rate; Hemoglobin; Markers; Maximum power; Measurement; Medical schools; Medicine; Medicine and health sciences; Metabolism; Mortality; Physical fitness; Physical Sciences; Physical training; Physiological aspects; Physiology; Regression analysis; Research and Analysis Methods; Studies; Type 1 diabetes
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0194750

This study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM). Sixty-four people with T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 ± 1% (62 ± 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by a second-degree polynomial representation between post-warm up and maximum power output. Adjusted stepwise linear regression analysis was performed to investigate kHR and its associations. Receiver operating characteristic (ROC) curve was performed based on kHR for groups kHR < 0.20 vs. > 0.20 in relation to HbA1c. We found significant relationships between kHR and HbA1c (β = -0.70, P < 0.0001), age (β = -0.23, P = 0.03) and duration of diabetes (β = 0.20, P = 0.04). Stepwise linear regression resulted in an overall adjusted R2 of 0.57 (R = 0.79, P < 0.0001). Our data revealed also significant associations between kHR and percentage of heart rate at heart rate turn point from maximum heart rate (β = 0.43, P < 0.0001) and maximum power output relativized to bodyweight (β = 0.44, P = 0.001) (overall adjusted R2 of 0.44 (R = 0.53, P < 0.0001)). ROC curve analysis based on kHR resulted in a HbA1c threshold of 7.9% (62 mmol.mol-1). Our data demonstrate atypical HRPC during CPX testing that were mainly related to glycemic control in people with T1DM.