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Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients
The impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer...
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Published in: | PloS one 2018-04, Vol.13 (4), p.e0195118-e0195118 |
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description | The impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer patients with palliative chemotherapy.
Between January 2005 and December 2016, two hundred and seventy-six patients who underwent chemotherapy for biliary tract cancer were retrospectively analyzed. The relationship between BMI (kg/m2) and clinical outcomes including overall and progression-free survival was assessed. Additionally the relationship between change in body composition and overall survival was evaluated.
Median overall survival was 9.7 months for underweight patients, 10.1 months for normal patients, 15.8 months for overweight group, 13.1 months for obese patients, respectively. (p = 0.047) Univariate analysis showed that BMI, stage III, age less than 64 year-old, gallbladder cancer, operation, radiotherapy and ECOG performance were significantly associated with better survival. Compared with normal patients, overweight patients (BMI 23-24.9kg/m2) had a reduced risk of mortality in multivariate analysis (HR 0.632; 95% CI 0.436-0.918, p = 0.016). In the additional analysis for the effect of changes in body weight and BMI to the overall survival, decrease in body weight and BMI (HR 1.410, 95% CI 1.168-1.986, p = 0.046) was associated with a shorter in overall survival.
Overweight status and the maintenance of body weight during the initial period of chemotherapy are important and independent predictors of better overall survival in advanced biliary tract cancer patients. |
doi_str_mv | 10.1371/journal.pone.0195118 |
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Between January 2005 and December 2016, two hundred and seventy-six patients who underwent chemotherapy for biliary tract cancer were retrospectively analyzed. The relationship between BMI (kg/m2) and clinical outcomes including overall and progression-free survival was assessed. Additionally the relationship between change in body composition and overall survival was evaluated.
Median overall survival was 9.7 months for underweight patients, 10.1 months for normal patients, 15.8 months for overweight group, 13.1 months for obese patients, respectively. (p = 0.047) Univariate analysis showed that BMI, stage III, age less than 64 year-old, gallbladder cancer, operation, radiotherapy and ECOG performance were significantly associated with better survival. Compared with normal patients, overweight patients (BMI 23-24.9kg/m2) had a reduced risk of mortality in multivariate analysis (HR 0.632; 95% CI 0.436-0.918, p = 0.016). In the additional analysis for the effect of changes in body weight and BMI to the overall survival, decrease in body weight and BMI (HR 1.410, 95% CI 1.168-1.986, p = 0.046) was associated with a shorter in overall survival.
Overweight status and the maintenance of body weight during the initial period of chemotherapy are important and independent predictors of better overall survival in advanced biliary tract cancer patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0195118</identifier><identifier>PMID: 29608578</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biliary tract ; Biliary tract cancer ; Biology and Life Sciences ; Body composition ; Body mass ; Body mass index ; Body size ; Body weight ; Cancer ; Care and treatment ; Chemotherapy ; Cholangiocarcinoma ; Chronic illnesses ; Development and progression ; Gallbladder ; Gallbladder cancer ; Health aspects ; Medical prognosis ; Medicine and Health Sciences ; Methods ; Mortality risk ; Multivariate analysis ; Nutrition ; Obesity ; Overweight ; Patient outcomes ; Patients ; Radiation therapy ; Risk reduction ; Sarcopenia ; Studies ; Survival ; Underweight</subject><ispartof>PloS one, 2018-04, Vol.13 (4), p.e0195118-e0195118</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Kang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Kang et al 2018 Kang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-9fb419900095155700bf9280f72a73fc9c0552df1888c74de743d327fedae03c3</citedby><cites>FETCH-LOGICAL-c692t-9fb419900095155700bf9280f72a73fc9c0552df1888c74de743d327fedae03c3</cites><orcidid>0000-0003-2174-9726</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2020854117/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2020854117?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29608578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Alpini, Gianfranco D.</contributor><creatorcontrib>Kang, Jinwoo</creatorcontrib><creatorcontrib>Lee, Sang Hyub</creatorcontrib><creatorcontrib>Son, Jun Hyuk</creatorcontrib><creatorcontrib>Lee, Jae Woo</creatorcontrib><creatorcontrib>Choi, Young Hoon</creatorcontrib><creatorcontrib>Choi, Jin Ho</creatorcontrib><creatorcontrib>Paik, Woo Hyun</creatorcontrib><creatorcontrib>Ryu, Ji Kon</creatorcontrib><creatorcontrib>Kim, Yong-Tae</creatorcontrib><title>Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer patients with palliative chemotherapy.
Between January 2005 and December 2016, two hundred and seventy-six patients who underwent chemotherapy for biliary tract cancer were retrospectively analyzed. The relationship between BMI (kg/m2) and clinical outcomes including overall and progression-free survival was assessed. Additionally the relationship between change in body composition and overall survival was evaluated.
Median overall survival was 9.7 months for underweight patients, 10.1 months for normal patients, 15.8 months for overweight group, 13.1 months for obese patients, respectively. (p = 0.047) Univariate analysis showed that BMI, stage III, age less than 64 year-old, gallbladder cancer, operation, radiotherapy and ECOG performance were significantly associated with better survival. Compared with normal patients, overweight patients (BMI 23-24.9kg/m2) had a reduced risk of mortality in multivariate analysis (HR 0.632; 95% CI 0.436-0.918, p = 0.016). In the additional analysis for the effect of changes in body weight and BMI to the overall survival, decrease in body weight and BMI (HR 1.410, 95% CI 1.168-1.986, p = 0.046) was associated with a shorter in overall survival.
Overweight status and the maintenance of body weight during the initial period of chemotherapy are important and independent predictors of better overall survival in advanced biliary tract cancer patients.</description><subject>Biliary tract</subject><subject>Biliary tract cancer</subject><subject>Biology and Life Sciences</subject><subject>Body composition</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Cholangiocarcinoma</subject><subject>Chronic illnesses</subject><subject>Development and progression</subject><subject>Gallbladder</subject><subject>Gallbladder cancer</subject><subject>Health aspects</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Mortality risk</subject><subject>Multivariate analysis</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Risk 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mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients</title><author>Kang, Jinwoo ; Lee, Sang Hyub ; Son, Jun Hyuk ; Lee, Jae Woo ; Choi, Young Hoon ; Choi, Jin Ho ; Paik, Woo Hyun ; Ryu, Ji Kon ; Kim, Yong-Tae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-9fb419900095155700bf9280f72a73fc9c0552df1888c74de743d327fedae03c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biliary tract</topic><topic>Biliary tract cancer</topic><topic>Biology and Life Sciences</topic><topic>Body composition</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Cholangiocarcinoma</topic><topic>Chronic illnesses</topic><topic>Development and 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Kon</au><au>Kim, Yong-Tae</au><au>Alpini, Gianfranco D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-04-02</date><risdate>2018</risdate><volume>13</volume><issue>4</issue><spage>e0195118</spage><epage>e0195118</epage><pages>e0195118-e0195118</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer patients with palliative chemotherapy.
Between January 2005 and December 2016, two hundred and seventy-six patients who underwent chemotherapy for biliary tract cancer were retrospectively analyzed. The relationship between BMI (kg/m2) and clinical outcomes including overall and progression-free survival was assessed. Additionally the relationship between change in body composition and overall survival was evaluated.
Median overall survival was 9.7 months for underweight patients, 10.1 months for normal patients, 15.8 months for overweight group, 13.1 months for obese patients, respectively. (p = 0.047) Univariate analysis showed that BMI, stage III, age less than 64 year-old, gallbladder cancer, operation, radiotherapy and ECOG performance were significantly associated with better survival. Compared with normal patients, overweight patients (BMI 23-24.9kg/m2) had a reduced risk of mortality in multivariate analysis (HR 0.632; 95% CI 0.436-0.918, p = 0.016). In the additional analysis for the effect of changes in body weight and BMI to the overall survival, decrease in body weight and BMI (HR 1.410, 95% CI 1.168-1.986, p = 0.046) was associated with a shorter in overall survival.
Overweight status and the maintenance of body weight during the initial period of chemotherapy are important and independent predictors of better overall survival in advanced biliary tract cancer patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29608578</pmid><doi>10.1371/journal.pone.0195118</doi><tpages>e0195118</tpages><orcidid>https://orcid.org/0000-0003-2174-9726</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Biliary tract Biliary tract cancer Biology and Life Sciences Body composition Body mass Body mass index Body size Body weight Cancer Care and treatment Chemotherapy Cholangiocarcinoma Chronic illnesses Development and progression Gallbladder Gallbladder cancer Health aspects Medical prognosis Medicine and Health Sciences Methods Mortality risk Multivariate analysis Nutrition Obesity Overweight Patient outcomes Patients Radiation therapy Risk reduction Sarcopenia Studies Survival Underweight |
title | Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients |
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