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Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients

The impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer...

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Published in:PloS one 2018-04, Vol.13 (4), p.e0195118-e0195118
Main Authors: Kang, Jinwoo, Lee, Sang Hyub, Son, Jun Hyuk, Lee, Jae Woo, Choi, Young Hoon, Choi, Jin Ho, Paik, Woo Hyun, Ryu, Ji Kon, Kim, Yong-Tae
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cited_by cdi_FETCH-LOGICAL-c692t-9fb419900095155700bf9280f72a73fc9c0552df1888c74de743d327fedae03c3
cites cdi_FETCH-LOGICAL-c692t-9fb419900095155700bf9280f72a73fc9c0552df1888c74de743d327fedae03c3
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container_title PloS one
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creator Kang, Jinwoo
Lee, Sang Hyub
Son, Jun Hyuk
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Ryu, Ji Kon
Kim, Yong-Tae
description The impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer patients with palliative chemotherapy. Between January 2005 and December 2016, two hundred and seventy-six patients who underwent chemotherapy for biliary tract cancer were retrospectively analyzed. The relationship between BMI (kg/m2) and clinical outcomes including overall and progression-free survival was assessed. Additionally the relationship between change in body composition and overall survival was evaluated. Median overall survival was 9.7 months for underweight patients, 10.1 months for normal patients, 15.8 months for overweight group, 13.1 months for obese patients, respectively. (p = 0.047) Univariate analysis showed that BMI, stage III, age less than 64 year-old, gallbladder cancer, operation, radiotherapy and ECOG performance were significantly associated with better survival. Compared with normal patients, overweight patients (BMI 23-24.9kg/m2) had a reduced risk of mortality in multivariate analysis (HR 0.632; 95% CI 0.436-0.918, p = 0.016). In the additional analysis for the effect of changes in body weight and BMI to the overall survival, decrease in body weight and BMI (HR 1.410, 95% CI 1.168-1.986, p = 0.046) was associated with a shorter in overall survival. Overweight status and the maintenance of body weight during the initial period of chemotherapy are important and independent predictors of better overall survival in advanced biliary tract cancer patients.
doi_str_mv 10.1371/journal.pone.0195118
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Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer patients with palliative chemotherapy. Between January 2005 and December 2016, two hundred and seventy-six patients who underwent chemotherapy for biliary tract cancer were retrospectively analyzed. The relationship between BMI (kg/m2) and clinical outcomes including overall and progression-free survival was assessed. Additionally the relationship between change in body composition and overall survival was evaluated. Median overall survival was 9.7 months for underweight patients, 10.1 months for normal patients, 15.8 months for overweight group, 13.1 months for obese patients, respectively. (p = 0.047) Univariate analysis showed that BMI, stage III, age less than 64 year-old, gallbladder cancer, operation, radiotherapy and ECOG performance were significantly associated with better survival. Compared with normal patients, overweight patients (BMI 23-24.9kg/m2) had a reduced risk of mortality in multivariate analysis (HR 0.632; 95% CI 0.436-0.918, p = 0.016). In the additional analysis for the effect of changes in body weight and BMI to the overall survival, decrease in body weight and BMI (HR 1.410, 95% CI 1.168-1.986, p = 0.046) was associated with a shorter in overall survival. 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Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer patients with palliative chemotherapy. Between January 2005 and December 2016, two hundred and seventy-six patients who underwent chemotherapy for biliary tract cancer were retrospectively analyzed. The relationship between BMI (kg/m2) and clinical outcomes including overall and progression-free survival was assessed. Additionally the relationship between change in body composition and overall survival was evaluated. Median overall survival was 9.7 months for underweight patients, 10.1 months for normal patients, 15.8 months for overweight group, 13.1 months for obese patients, respectively. (p = 0.047) Univariate analysis showed that BMI, stage III, age less than 64 year-old, gallbladder cancer, operation, radiotherapy and ECOG performance were significantly associated with better survival. Compared with normal patients, overweight patients (BMI 23-24.9kg/m2) had a reduced risk of mortality in multivariate analysis (HR 0.632; 95% CI 0.436-0.918, p = 0.016). In the additional analysis for the effect of changes in body weight and BMI to the overall survival, decrease in body weight and BMI (HR 1.410, 95% CI 1.168-1.986, p = 0.046) was associated with a shorter in overall survival. Overweight status and the maintenance of body weight during the initial period of chemotherapy are important and independent predictors of better overall survival in advanced biliary tract cancer patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29608578</pmid><doi>10.1371/journal.pone.0195118</doi><tpages>e0195118</tpages><orcidid>https://orcid.org/0000-0003-2174-9726</orcidid><oa>free_for_read</oa></addata></record>
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1932-6203
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subjects Biliary tract
Biliary tract cancer
Biology and Life Sciences
Body composition
Body mass
Body mass index
Body size
Body weight
Cancer
Care and treatment
Chemotherapy
Cholangiocarcinoma
Chronic illnesses
Development and progression
Gallbladder
Gallbladder cancer
Health aspects
Medical prognosis
Medicine and Health Sciences
Methods
Mortality risk
Multivariate analysis
Nutrition
Obesity
Overweight
Patient outcomes
Patients
Radiation therapy
Risk reduction
Sarcopenia
Studies
Survival
Underweight
title Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients
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