Childhood obesity treatment; Effects on BMI SDS, body composition, and fasting plasma lipid concentrations

The body mass index (BMI) standard deviation score (SDS) may not adequately reflect changes in fat mass during childhood obesity treatment. This study aimed to investigate associations between BMI SDS, body composition, and fasting plasma lipid concentrations at baseline and during childhood obesity...

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Bibliographic Details
Published in:PloS one 2018-02, Vol.13 (2), p.e0190576-e0190576
Main Authors: Nielsen, Tenna Ruest Haarmark, Fonvig, Cilius Esmann, Dahl, Maria, Mollerup, Pernille Maria, Lausten-Thomsen, Ulrik, Pedersen, Oluf, Hansen, Torben, Holm, Jens-Christian
Format: Article
Language:English
Subjects:
Adolescents
Analysis
Biology and Life Sciences
Body composition
Body fat
Body mass
Body mass index
Body size
Body weight
Cardiovascular disease
Childhood obesity
Children
Cholesterol
Composition effects
Drug therapy
Dual energy X-ray absorptiometry
Energy measurement
Fasting
Girls
High density lipoprotein
Laboratory testing
Lipids
Low density lipoprotein
Medicine and Health Sciences
Obesity
Overweight
People and Places
Physiological aspects
Risk factors
Teenagers
Triglycerides
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Summary:The body mass index (BMI) standard deviation score (SDS) may not adequately reflect changes in fat mass during childhood obesity treatment. This study aimed to investigate associations between BMI SDS, body composition, and fasting plasma lipid concentrations at baseline and during childhood obesity treatment. 876 children and adolescents (498 girls) with overweight/obesity, median age 11.2 years (range 1.6-21.7), and median BMI SDS 2.8 (range 1.3-5.7) were enrolled in a multidisciplinary outpatient treatment program and followed for a median of 1.8 years (range 0.4-7.4). Height and weight, body composition measured by dual-energy X-ray absorptiometry, and fasting plasma lipid concentrations were assessed at baseline and at follow-up. Lipid concentrations (total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), non-HDL, and triglycerides (TG)) were available in 469 individuals (264 girls). Linear regressions were performed to investigate the associations between BMI SDS, body composition indices, and lipid concentrations. At baseline, BMI SDS was negatively associated with concentrations of HDL (p = 6.7*10-4) and positively with TG (p = 9.7*10-6). Reductions in BMI SDS were associated with reductions in total body fat percentage (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0190576