Assessment of veins in T2-weighted MR angiography predicts infarct growth in hyperacute ischemic stroke

• Published in: PloS one 2018-04, Vol.13 (4), p.e0195554-e0195554
• Main Authors: Yamaguchi, Susumu, Horie, Nobutaka, Morikawa, Minoru, Tateishi, Yohei, Hiu, Takeshi, Morofuji, Yoichi, Izumo, Tsuyoshi, Hayashi, Kentaro, Matsuo, Takayuki
• Format: Article
• Language: English
• Subjects: Angiography; Biology and Life Sciences; Care and treatment; Complications and side effects; Computed tomography; Correlation; Cortex; Etiology; Ischemia; Lesions; Magnetic resonance; Magnetic resonance angiography; Magnetic resonance imaging; Medical imaging; Medicine and Health Sciences; Methods; Neurosurgery; NMR; Nuclear magnetic resonance; Occlusion; Patients; Regression analysis; Research and Analysis Methods; Resonance; Risk factors; Stem cells; Stroke; Veins; Veins & arteries
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0195554

T2*-weighted magnetic resonance angiography (SWAN) detects hemodynamic insufficiency as hypointense areas in medullary or cortical veins. We therefore investigated whether SWAN can help predict ischemic penumbra-like lesions in patients with acute ischemic stroke (AIS). Magnetic resonance imaging (MRI) records-including SWAN, diffusion-weighted imaging (DWI), and magnetic resonance angiography (MRA)-of consecutive patients with major vessel occlusion within 6 h from AIS onset were analyzed. Acute recanalization was defined as an arterial occlusive lesion score of 2-3. A modified Alberta Stroke Program Early CT Score (mASPECTS) was used to evaluate ischemic areas revealed by SWAN and DWI. SWAN- and DWI-based mASPECTSs were calculated, and correlations between DWI-SWAN mismatches with final infarct lesions or clinical outcomes were evaluated. Among the 35 patients included in this study, we confirmed cardioembolic stroke in 26, atherothrombotic stroke in 4, and unknown stroke etiology in 5. Overall, recanalization was achieved in 23 patients, who showed a higher follow-up DWI-based mASPECTS and lower modified Rankin Scale (mRS) score at 90 days than patients without recanalization. Initial SWAN- and follow-up DWI-based mASPECTSs were significantly higher for atherothrombotic stroke than for cardioembolic stroke. Of 12 patients without recanalization, DWI-SWAN mismatch was significantly correlated with infarct growth. Patients with recanalization showed no such correlation. In the assessment of clinical outcome, follow-up DWI-based mASPECTS and patient's age were significantly correlated with mRS at 90 days after stroke. A multivariate logistic regression analysis revealed that the follow-up DWI-based mASPECTS was independently associated with a favorable outcome 90 days after stroke. For patients with AIS, DWI-SWAN mismatch might show penumbra-like lesions that would predict infarct growth without acute recanalization. Assessment of ischemic lesions from the venous side appears to be useful for considering the etiology and revascularization therapy.