Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS

Decreased but measurable serum IgA levels (≤70 mg/dL) have been associated with risk for infections in some populations, but are unstudied in COPD. This study tested the hypothesis that subnormal serum IgA levels would be associated with exacerbation risk in COPD. Data were analyzed from 1,049 COPD...

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Bibliographic Details
Published in:PloS one 2018-04, Vol.13 (4), p.e0194924-e0194924
Main Authors: Putcha, Nirupama, Paul, Gabriel G, Azar, Antoine, Wise, Robert A, O'Neal, Wanda K, Dransfield, Mark T, Woodruff, Prescott G, Curtis, Jeffrey L, Comellas, Alejandro P, Drummond, M Bradley, Lambert, Allison A, Paulin, Laura M, Fawzy, Ashraf, Kanner, Richard E, Paine, 3rd, Robert, Han, MeiLan K, Martinez, Fernando J, Bowler, Russell P, Barr, R Graham, Hansel, Nadia N
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antibiotics
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Care and treatment
Chronic obstructive lung disease
Chronic obstructive pulmonary disease
Cohort Studies
Data processing
Disease
Disease Progression
Female
Health aspects
Health risks
Humans
Immune status
Immunoglobulin A
Immunoglobulin A - blood
Immunoglobulin A - immunology
Immunoglobulins
Incidence
Infection
Male
Medicine
Medicine and Health Sciences
Middle Aged
Morbidity
Population
Pulmonary Disease, Chronic Obstructive - blood
Pulmonary Disease, Chronic Obstructive - physiopathology
Regression Analysis
Risk
Risk factors
Therapeutics
Treatment Outcome
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Summary:Decreased but measurable serum IgA levels (≤70 mg/dL) have been associated with risk for infections in some populations, but are unstudied in COPD. This study tested the hypothesis that subnormal serum IgA levels would be associated with exacerbation risk in COPD. Data were analyzed from 1,049 COPD participants from the observational cohort study SPIROMICS (535 (51%) women; mean age 66.1 (SD 7.8), 338 (32%) current smokers) who had baseline serum IgA measured using the Myriad RBM biomarker discovery platform. Exacerbation data was collected prospectively (mean 944.3 (SD 281.3) days), and adjusted linear, logistic and zero-inflated negative binomial regressions were performed. Mean IgA was 269.1 mg/dL (SD 150.9). One individual had deficient levels of serum IgA (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0194924