Prevalent hepatitis B surface antigen among first-time blood donors in Gabon

Despite chronic Hepatitis B virus (HBV) infection being the main cause of younger-onset complex liver disease including cirrhosis and hepatocellular carcinoma (HCC) in Africa, very little is known regarding the seroprevalence of HBV in the Gabonese general population. This investigation aimed to pro...

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Bibliographic Details
Published in:PloS one 2018-04, Vol.13 (4), p.e0194285-e0194285
Main Authors: Eko Mba, Jean Marie, Bisseye, Cyrille, Ntsame Ndong, Jophrette Mireille, Mombo, Landry Erik, Bengone, Calixte, Mouelet Migolet, Guy, M'batchi, Bertrand, Kosiorek, Heidi E, Butterfield, Richard J, Roberts, Lewis R, Borad, Mitesh J, Nagalo, Bolni Marius
Format: Article
Language:English
Subjects:
Age
Annual variations
Antigens
Biology and life sciences
Blood
Blood & organ donations
Blood donation
Blood donors
Blood products
Blood transfusions
Chronic infection
Cirrhosis
Distribution
Enzyme-linked immunosorbent assay
Epidemiology
Family medical history
Females
Health aspects
Health risks
Hematology
Hepatitis
Hepatitis B
Hepatitis B surface antigen
Hepatitis virus tests
Hepatocellular carcinoma
Hospitals
Immunization
Infections
Infectious diseases
Liver
Liver cancer
Liver cirrhosis
Liver diseases
Males
Medicine and Health Sciences
Methods
Pan-Africanism
People and Places
Population
Public health
Risk analysis
Risk factors
Serology
Syphilis
Viral infections
Viruses
Womens health
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Summary:Despite chronic Hepatitis B virus (HBV) infection being the main cause of younger-onset complex liver disease including cirrhosis and hepatocellular carcinoma (HCC) in Africa, very little is known regarding the seroprevalence of HBV in the Gabonese general population. This investigation aimed to provide strong epidemiological data and risk factors associated with HBV infection in first-time blood donors representative of the urban adult population. The screening of HBsAg was carried out using 4th generation ELISA kits. The overall seroprevalence of HBsAg was 7.28%. The frequency of HBsAg was differential and marked by annual variations in blood donors from 2009 to 2016. Seroprevalence was 2-fold higher among males versus females (OR = 1.90 (95% CI: 1.75-2.06), P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0194285