Pattern and Rate of Cognitive Decline in Cerebral Small Vessel Disease: A Prospective Study

Cognitive impairment, predominantly affecting processing speed and executive function, is an important consequence of cerebral small vessel disease (SVD). To date, few longitudinal studies of cognition in SVD have been conducted. We determined the pattern and rate of cognitive decline in SVD and use...

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Bibliographic Details
Published in:PloS one 2015-08, Vol.10 (8), p.e0135523-e0135523
Main Authors: Lawrence, Andrew J, Brookes, Rebecca L, Zeestraten, Eva A, Barrick, Thomas R, Morris, Robin G, Markus, Hugh S
Format: Article
Language:English
Subjects:
Activities of daily living
Age
Aged
Batteries
Cerebral Small Vessel Diseases - physiopathology
Clinical trials
Cognition
Cognition & reasoning
Cognition - physiology
Cognition Disorders - physiopathology
Cognitive ability
Correlation analysis
Dementia
Executive function
Female
Humans
Information processing
Leukoaraiosis
Longitudinal Studies
Magnetic resonance imaging
Male
Mathematical analysis
Medical imaging
Medical research
Memory, Short-Term - physiology
Middle Aged
Neuroimaging
Neurology
Neuropsychological Tests
Neurosciences
NMR
Nuclear magnetic resonance
Patients
Prospective Studies
Psychiatry
Short term memory
Stroke
Studies
Vascular diseases
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Summary:Cognitive impairment, predominantly affecting processing speed and executive function, is an important consequence of cerebral small vessel disease (SVD). To date, few longitudinal studies of cognition in SVD have been conducted. We determined the pattern and rate of cognitive decline in SVD and used the results to determine sample size calculations for clinical trials of interventions reducing cognitive decline. 121 patients with MRI confirmed lacunar stroke and leukoaraiosis were enrolled into the prospective St George's Cognition And Neuroimaging in Stroke (SCANS) study. Patients attended one baseline and three annual cognitive assessments providing 36 month follow-up data. Neuropsychological assessment comprised a battery of tests assessing working memory, long-term (episodic) memory, processing speed and executive function. We calculated annualized change in cognition for the 98 patients who completed at least two time-points. Task performance was heterogeneous, but significant cognitive decline was found for the executive function index (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0135523