Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1

Lyme disease is caused by spirochaetes of the Borrelia burgdorferi sensu lato genospecies. Complete genome assemblies are available for fewer than ten strains of Borrelia burgdorferi sensu stricto, the primary cause of Lyme disease in North America. MM1 is a sensu stricto strain originally isolated...

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Bibliographic Details
Published in:PloS one 2018-06, Vol.13 (6), p.e0198135-e0198135
Main Authors: Jabbari, Neda, Glusman, Gustavo, Joesch-Cohen, Lena M, Reddy, Panga Jaipal, Moritz, Robert L, Hood, Leroy, Lausted, Christopher G
Format: Article
Language:English
Subjects:
Animals
Antigens
Arachnids
Arthritis
Bacterial Typing Techniques
Biology
Biology and Life Sciences
Borrelia
Borrelia afzelii
Borrelia burgdorferi
Borrelia burgdorferi - classification
Borrelia burgdorferi - genetics
Borrelia burgdorferi Group - genetics
Causes of
Chromosome Mapping
Chromosomes
Comparative analysis
Comparative Genomic Hybridization
Conserved sequence
Deoxyribonucleic acid
DNA
DNA sequencing
DNA, Bacterial - analysis
Evolution & development
Genetic aspects
Genetic diversity
Genetic Variation
Genome, Bacterial
Genomes
Genomics
High-Throughput Nucleotide Sequencing - methods
Humans
Laboratories
Lyme disease
Lyme Disease - microbiology
Medicine and Health Sciences
Multilocus Sequence Typing
Nucleotide sequence
Peromyscus leucopus
Plasmids
Proteins
Research and Analysis Methods
Vector-borne diseases
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Summary:Lyme disease is caused by spirochaetes of the Borrelia burgdorferi sensu lato genospecies. Complete genome assemblies are available for fewer than ten strains of Borrelia burgdorferi sensu stricto, the primary cause of Lyme disease in North America. MM1 is a sensu stricto strain originally isolated in the midwestern United States. Aside from a small number of genes, the complete genome sequence of this strain has not been reported. Here we present the complete genome sequence of MM1 in relation to other sensu stricto strains and in terms of its Multi Locus Sequence Typing. Our results indicate that MM1 is a new sequence type which contains a conserved main chromosome and 15 plasmids. Our results include the first contiguous 28.5 kb assembly of lp28-8, a linear plasmid carrying the vls antigenic variation system, from a Borrelia burgdorferi sensu stricto strain.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0198135