Botulinum toxin chemodenervation for childhood strabismus in England: National and local patterns of practice

Botulinum toxin injection chemodenervation is a well-established intervention for adult strabismus, and has also been recognised as an effective alternative to routine incisional surgery for paediatric disease. We aimed to investigate the temporal patterns of practice, indications and outcomes of ch...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2018-06, Vol.13 (6), p.e0199074-e0199074
Main Authors: Solebo, Ameenat Lola, Austin, Anne-Marie, Theodorou, Maria, Timms, Chris, Hancox, Joanne, Adams, Gillian G W
Format: Article
Language:English
Subjects:
Analysis
Biology and Life Sciences
Biomedical research
Botulinum toxin
Botulinum toxins
Botulinum Toxins - adverse effects
Botulinum Toxins - pharmacology
Botulinum Toxins - therapeutic use
Care and treatment
Child
Childhood
Children
Clinical decision making
Decision making
Dosage and administration
England
Health aspects
Hemorrhage
Humans
Injection
Intervention
Median (statistics)
Medical research
Medicine and Health Sciences
Nerve Block - adverse effects
Pediatrics
Research and Analysis Methods
Retrospective Studies
Safety
Strabismus
Strabismus - drug therapy
Subgroups
Surgery
Systematic review
Toxins
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Botulinum toxin injection chemodenervation is a well-established intervention for adult strabismus, and has also been recognised as an effective alternative to routine incisional surgery for paediatric disease. We aimed to investigate the temporal patterns of practice, indications and outcomes of chemodenervation for paediatric strabismus at national and tertiary centre level. Retrospective study using routinely collected patient data: Hospital Episode Statistics (HES) data were used to identify children undergoing non-incisional strabismus procedures in England from 2007 to 2016. Single-centre retrospective data on children undergoing botulinum toxin injections (Dysport® 2.5 units/ 0.1ml) as an isolated intervention (not involving incisional procedures) was undertaken to identify indications and outcomes. Successful outcome was defined as deviation
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0199074