Vasodilator effects of dehydroepiandrosterone (DHEA) on fetal pulmonary circulation: An experimental study in pregnant sheep

Persistent pulmonary hypertension (PPHN) remains a severe complication of the transition to extra-uterine life with significant morbidity and mortality in the newborns. Dehydroepiandrosterone (DHEA) represents a new pharmacological agent with vascular effects, including improvement of PPHN in severa...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2018-06, Vol.13 (6), p.e0198778
Main Authors: Sharma, Dyuti, Coridon, Hélène, Aubry, Estelle, Houeijeh, Ali, Houfflin-Debarge, Véronique, Besson, Rémi, Deruelle, Philippe, Storme, Laurent
Format: Article
Language:English
Subjects:
Animal models
Animals
Biology and Life Sciences
Blood
Blood circulation
Chronic obstructive pulmonary disease
Dehydroepiandrosterone
Dehydroepiandrosterone - pharmacology
Disease
Dose-Response Relationship, Drug
Female
Fetal development
Fetus - blood supply
Fetuses
Gases
Gestation
Gynecology
Health aspects
Hospitals
Hypertension
Intravenous administration
Intravenous infusion
Measurement
Medicine and Health Sciences
Morbidity
Neonates
Nitric oxide
Obstetrics
Ostomy
Ovis aries
Pediatrics
Pharmacology
Physical Sciences
Physiology
Pregnancy
Pulmonary arteries
Pulmonary circulation
Pulmonary Circulation - drug effects
Pulmonary hypertension
Sheep
Studies
Surgery
Testing
Time Factors
Uterus
Vasodilator Agents - pharmacology
Veins & arteries
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c593t-f7cc2f53d6d17183de0f68d2ed8318d55efc7165d6a8f6731acd84847f6319803
cites cdi_FETCH-LOGICAL-c593t-f7cc2f53d6d17183de0f68d2ed8318d55efc7165d6a8f6731acd84847f6319803
container_end_page
container_issue 6
container_start_page e0198778
container_title PloS one
container_volume 13
creator Sharma, Dyuti
Coridon, Hélène
Aubry, Estelle
Houeijeh, Ali
Houfflin-Debarge, Véronique
Besson, Rémi
Deruelle, Philippe
Storme, Laurent
description Persistent pulmonary hypertension (PPHN) remains a severe complication of the transition to extra-uterine life with significant morbidity and mortality in the newborns. Dehydroepiandrosterone (DHEA) represents a new pharmacological agent with vascular effects, including improvement of PPHN in several animal models. We hypothesized that DHEA could decrease pulmonary vascular resistance (PVR) in the pulmonary circulation of fetal sheep. We studied the effect of intravenous infusion of DHEA in fetal lambs using chronically instrumented sheep at 128 days of gestation. PVR was computed before and after intravenous infusion of increasing doses of DHEA. We assessed pre-treatment by L-nitroarginine, an inhibitor of NO production. Blood gases and doses of DHEA were measured in both sheep and fetus before/after DHEA infusion. Intravenous infusion of DHEA had a vasodilator effect with a significant decrease in PVR (respectively -11%, -14% and -36% after infusion of 6, 12 and 24 mg DHEA, p
doi_str_mv 10.1371/journal.pone.0198778
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2060855402</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A547840832</galeid><doaj_id>oai_doaj_org_article_7941f6aba6de491aae11132c5a13fa70</doaj_id><sourcerecordid>A547840832</sourcerecordid><originalsourceid>FETCH-LOGICAL-c593t-f7cc2f53d6d17183de0f68d2ed8318d55efc7165d6a8f6731acd84847f6319803</originalsourceid><addsrcrecordid>eNp1Uk1v1DAQjRCIlsI_QGCJCxx2seP4Iz0grUqhlSpxAa6Wa493vcrawU4QK_Hjcdi06kogH8Yav3nzZvyq6iXBS0IFeb-NYwq6W_YxwBKTVgohH1WnpKX1gteYPn5wP6me5bzFmFHJ-dPqpG7bpuU1Pa1-f9c5Wt_pISYEzoEZMooOWdjsbYrQex1KzAOk0ge9_Xh1uXqHYkAOBt2hfux2Mei0R8YnMxYaH8M5WgUEv3pIfgdhguVhtHvkA-oTrIMOA8obgP559cTpLsOLOZ5V3z5dfr24Wtx8-Xx9sbpZGNbSYeGEMbVj1HJLBJHUAnZc2hqspERaxsAZQTizXEvHBSXaWNnIRjhOy14wPateH3j7LmY1Ly6rGnMsGWtwXRDXB4SNeqv6IrzMpKL26m8iprXSafCmAyXahjiubzW30LREayCE0NowTajTYur2Ye423u7AmrKCpLsj0uOX4DdqHX8qjmuCG1oI3swEKf4YIQ__kTyj1rqo8sHFQmZ2Phu1Yo2QDZZ0Qi3_gSrHws6b8qXOl_xRQXMoMOXXcwJ3L5xgNRnvToyajKdm45WyVw-Hvi-6cxr9AzM818Y</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2060855402</pqid></control><display><type>article</type><title>Vasodilator effects of dehydroepiandrosterone (DHEA) on fetal pulmonary circulation: An experimental study in pregnant sheep</title><source>Open Access: PubMed Central</source><source>Publicly Available Content (ProQuest)</source><creator>Sharma, Dyuti ; Coridon, Hélène ; Aubry, Estelle ; Houeijeh, Ali ; Houfflin-Debarge, Véronique ; Besson, Rémi ; Deruelle, Philippe ; Storme, Laurent</creator><contributor>Ashton, Nick</contributor><creatorcontrib>Sharma, Dyuti ; Coridon, Hélène ; Aubry, Estelle ; Houeijeh, Ali ; Houfflin-Debarge, Véronique ; Besson, Rémi ; Deruelle, Philippe ; Storme, Laurent ; Ashton, Nick</creatorcontrib><description>Persistent pulmonary hypertension (PPHN) remains a severe complication of the transition to extra-uterine life with significant morbidity and mortality in the newborns. Dehydroepiandrosterone (DHEA) represents a new pharmacological agent with vascular effects, including improvement of PPHN in several animal models. We hypothesized that DHEA could decrease pulmonary vascular resistance (PVR) in the pulmonary circulation of fetal sheep. We studied the effect of intravenous infusion of DHEA in fetal lambs using chronically instrumented sheep at 128 days of gestation. PVR was computed before and after intravenous infusion of increasing doses of DHEA. We assessed pre-treatment by L-nitroarginine, an inhibitor of NO production. Blood gases and doses of DHEA were measured in both sheep and fetus before/after DHEA infusion. Intravenous infusion of DHEA had a vasodilator effect with a significant decrease in PVR (respectively -11%, -14% and -36% after infusion of 6, 12 and 24 mg DHEA, p&lt;0.01) without damaging effects on systemic circulation or on blood gases. The inhibitory effect of pre-treatment with L-nitroarginine resulted in a significant increase in PVR. We demonstrated a potent vasodilator effect of DHEA on fetal pulmonary circulation without deleterious effects. DHEA might represent a new treatment for PPHN.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0198778</identifier><identifier>PMID: 29949623</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animal models ; Animals ; Biology and Life Sciences ; Blood ; Blood circulation ; Chronic obstructive pulmonary disease ; Dehydroepiandrosterone ; Dehydroepiandrosterone - pharmacology ; Disease ; Dose-Response Relationship, Drug ; Female ; Fetal development ; Fetus - blood supply ; Fetuses ; Gases ; Gestation ; Gynecology ; Health aspects ; Hospitals ; Hypertension ; Intravenous administration ; Intravenous infusion ; Measurement ; Medicine and Health Sciences ; Morbidity ; Neonates ; Nitric oxide ; Obstetrics ; Ostomy ; Ovis aries ; Pediatrics ; Pharmacology ; Physical Sciences ; Physiology ; Pregnancy ; Pulmonary arteries ; Pulmonary circulation ; Pulmonary Circulation - drug effects ; Pulmonary hypertension ; Sheep ; Studies ; Surgery ; Testing ; Time Factors ; Uterus ; Vasodilator Agents - pharmacology ; Veins &amp; arteries</subject><ispartof>PloS one, 2018-06, Vol.13 (6), p.e0198778</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Sharma et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Sharma et al 2018 Sharma et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-f7cc2f53d6d17183de0f68d2ed8318d55efc7165d6a8f6731acd84847f6319803</citedby><cites>FETCH-LOGICAL-c593t-f7cc2f53d6d17183de0f68d2ed8318d55efc7165d6a8f6731acd84847f6319803</cites><orcidid>0000-0001-6752-8123</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2060855402/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2060855402?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29949623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ashton, Nick</contributor><creatorcontrib>Sharma, Dyuti</creatorcontrib><creatorcontrib>Coridon, Hélène</creatorcontrib><creatorcontrib>Aubry, Estelle</creatorcontrib><creatorcontrib>Houeijeh, Ali</creatorcontrib><creatorcontrib>Houfflin-Debarge, Véronique</creatorcontrib><creatorcontrib>Besson, Rémi</creatorcontrib><creatorcontrib>Deruelle, Philippe</creatorcontrib><creatorcontrib>Storme, Laurent</creatorcontrib><title>Vasodilator effects of dehydroepiandrosterone (DHEA) on fetal pulmonary circulation: An experimental study in pregnant sheep</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Persistent pulmonary hypertension (PPHN) remains a severe complication of the transition to extra-uterine life with significant morbidity and mortality in the newborns. Dehydroepiandrosterone (DHEA) represents a new pharmacological agent with vascular effects, including improvement of PPHN in several animal models. We hypothesized that DHEA could decrease pulmonary vascular resistance (PVR) in the pulmonary circulation of fetal sheep. We studied the effect of intravenous infusion of DHEA in fetal lambs using chronically instrumented sheep at 128 days of gestation. PVR was computed before and after intravenous infusion of increasing doses of DHEA. We assessed pre-treatment by L-nitroarginine, an inhibitor of NO production. Blood gases and doses of DHEA were measured in both sheep and fetus before/after DHEA infusion. Intravenous infusion of DHEA had a vasodilator effect with a significant decrease in PVR (respectively -11%, -14% and -36% after infusion of 6, 12 and 24 mg DHEA, p&lt;0.01) without damaging effects on systemic circulation or on blood gases. The inhibitory effect of pre-treatment with L-nitroarginine resulted in a significant increase in PVR. We demonstrated a potent vasodilator effect of DHEA on fetal pulmonary circulation without deleterious effects. DHEA might represent a new treatment for PPHN.</description><subject>Animal models</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood circulation</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Dehydroepiandrosterone</subject><subject>Dehydroepiandrosterone - pharmacology</subject><subject>Disease</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fetal development</subject><subject>Fetus - blood supply</subject><subject>Fetuses</subject><subject>Gases</subject><subject>Gestation</subject><subject>Gynecology</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Intravenous administration</subject><subject>Intravenous infusion</subject><subject>Measurement</subject><subject>Medicine and Health Sciences</subject><subject>Morbidity</subject><subject>Neonates</subject><subject>Nitric oxide</subject><subject>Obstetrics</subject><subject>Ostomy</subject><subject>Ovis aries</subject><subject>Pediatrics</subject><subject>Pharmacology</subject><subject>Physical Sciences</subject><subject>Physiology</subject><subject>Pregnancy</subject><subject>Pulmonary arteries</subject><subject>Pulmonary circulation</subject><subject>Pulmonary Circulation - drug effects</subject><subject>Pulmonary hypertension</subject><subject>Sheep</subject><subject>Studies</subject><subject>Surgery</subject><subject>Testing</subject><subject>Time Factors</subject><subject>Uterus</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Veins &amp; arteries</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1Uk1v1DAQjRCIlsI_QGCJCxx2seP4Iz0grUqhlSpxAa6Wa493vcrawU4QK_Hjcdi06kogH8Yav3nzZvyq6iXBS0IFeb-NYwq6W_YxwBKTVgohH1WnpKX1gteYPn5wP6me5bzFmFHJ-dPqpG7bpuU1Pa1-f9c5Wt_pISYEzoEZMooOWdjsbYrQex1KzAOk0ge9_Xh1uXqHYkAOBt2hfux2Mei0R8YnMxYaH8M5WgUEv3pIfgdhguVhtHvkA-oTrIMOA8obgP559cTpLsOLOZ5V3z5dfr24Wtx8-Xx9sbpZGNbSYeGEMbVj1HJLBJHUAnZc2hqspERaxsAZQTizXEvHBSXaWNnIRjhOy14wPateH3j7LmY1Ly6rGnMsGWtwXRDXB4SNeqv6IrzMpKL26m8iprXSafCmAyXahjiubzW30LREayCE0NowTajTYur2Ye423u7AmrKCpLsj0uOX4DdqHX8qjmuCG1oI3swEKf4YIQ__kTyj1rqo8sHFQmZ2Phu1Yo2QDZZ0Qi3_gSrHws6b8qXOl_xRQXMoMOXXcwJ3L5xgNRnvToyajKdm45WyVw-Hvi-6cxr9AzM818Y</recordid><startdate>20180627</startdate><enddate>20180627</enddate><creator>Sharma, Dyuti</creator><creator>Coridon, Hélène</creator><creator>Aubry, Estelle</creator><creator>Houeijeh, Ali</creator><creator>Houfflin-Debarge, Véronique</creator><creator>Besson, Rémi</creator><creator>Deruelle, Philippe</creator><creator>Storme, Laurent</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6752-8123</orcidid></search><sort><creationdate>20180627</creationdate><title>Vasodilator effects of dehydroepiandrosterone (DHEA) on fetal pulmonary circulation: An experimental study in pregnant sheep</title><author>Sharma, Dyuti ; Coridon, Hélène ; Aubry, Estelle ; Houeijeh, Ali ; Houfflin-Debarge, Véronique ; Besson, Rémi ; Deruelle, Philippe ; Storme, Laurent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-f7cc2f53d6d17183de0f68d2ed8318d55efc7165d6a8f6731acd84847f6319803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Blood circulation</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Dehydroepiandrosterone</topic><topic>Dehydroepiandrosterone - pharmacology</topic><topic>Disease</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fetal development</topic><topic>Fetus - blood supply</topic><topic>Fetuses</topic><topic>Gases</topic><topic>Gestation</topic><topic>Gynecology</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>Intravenous administration</topic><topic>Intravenous infusion</topic><topic>Measurement</topic><topic>Medicine and Health Sciences</topic><topic>Morbidity</topic><topic>Neonates</topic><topic>Nitric oxide</topic><topic>Obstetrics</topic><topic>Ostomy</topic><topic>Ovis aries</topic><topic>Pediatrics</topic><topic>Pharmacology</topic><topic>Physical Sciences</topic><topic>Physiology</topic><topic>Pregnancy</topic><topic>Pulmonary arteries</topic><topic>Pulmonary circulation</topic><topic>Pulmonary Circulation - drug effects</topic><topic>Pulmonary hypertension</topic><topic>Sheep</topic><topic>Studies</topic><topic>Surgery</topic><topic>Testing</topic><topic>Time Factors</topic><topic>Uterus</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Veins &amp; arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Dyuti</creatorcontrib><creatorcontrib>Coridon, Hélène</creatorcontrib><creatorcontrib>Aubry, Estelle</creatorcontrib><creatorcontrib>Houeijeh, Ali</creatorcontrib><creatorcontrib>Houfflin-Debarge, Véronique</creatorcontrib><creatorcontrib>Besson, Rémi</creatorcontrib><creatorcontrib>Deruelle, Philippe</creatorcontrib><creatorcontrib>Storme, Laurent</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database (ProQuest)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Dyuti</au><au>Coridon, Hélène</au><au>Aubry, Estelle</au><au>Houeijeh, Ali</au><au>Houfflin-Debarge, Véronique</au><au>Besson, Rémi</au><au>Deruelle, Philippe</au><au>Storme, Laurent</au><au>Ashton, Nick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vasodilator effects of dehydroepiandrosterone (DHEA) on fetal pulmonary circulation: An experimental study in pregnant sheep</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-06-27</date><risdate>2018</risdate><volume>13</volume><issue>6</issue><spage>e0198778</spage><pages>e0198778-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Persistent pulmonary hypertension (PPHN) remains a severe complication of the transition to extra-uterine life with significant morbidity and mortality in the newborns. Dehydroepiandrosterone (DHEA) represents a new pharmacological agent with vascular effects, including improvement of PPHN in several animal models. We hypothesized that DHEA could decrease pulmonary vascular resistance (PVR) in the pulmonary circulation of fetal sheep. We studied the effect of intravenous infusion of DHEA in fetal lambs using chronically instrumented sheep at 128 days of gestation. PVR was computed before and after intravenous infusion of increasing doses of DHEA. We assessed pre-treatment by L-nitroarginine, an inhibitor of NO production. Blood gases and doses of DHEA were measured in both sheep and fetus before/after DHEA infusion. Intravenous infusion of DHEA had a vasodilator effect with a significant decrease in PVR (respectively -11%, -14% and -36% after infusion of 6, 12 and 24 mg DHEA, p&lt;0.01) without damaging effects on systemic circulation or on blood gases. The inhibitory effect of pre-treatment with L-nitroarginine resulted in a significant increase in PVR. We demonstrated a potent vasodilator effect of DHEA on fetal pulmonary circulation without deleterious effects. DHEA might represent a new treatment for PPHN.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29949623</pmid><doi>10.1371/journal.pone.0198778</doi><orcidid>https://orcid.org/0000-0001-6752-8123</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2018-06, Vol.13 (6), p.e0198778
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2060855402
source Open Access: PubMed Central; Publicly Available Content (ProQuest)
subjects Animal models
Animals
Biology and Life Sciences
Blood
Blood circulation
Chronic obstructive pulmonary disease
Dehydroepiandrosterone
Dehydroepiandrosterone - pharmacology
Disease
Dose-Response Relationship, Drug
Female
Fetal development
Fetus - blood supply
Fetuses
Gases
Gestation
Gynecology
Health aspects
Hospitals
Hypertension
Intravenous administration
Intravenous infusion
Measurement
Medicine and Health Sciences
Morbidity
Neonates
Nitric oxide
Obstetrics
Ostomy
Ovis aries
Pediatrics
Pharmacology
Physical Sciences
Physiology
Pregnancy
Pulmonary arteries
Pulmonary circulation
Pulmonary Circulation - drug effects
Pulmonary hypertension
Sheep
Studies
Surgery
Testing
Time Factors
Uterus
Vasodilator Agents - pharmacology
Veins & arteries
title Vasodilator effects of dehydroepiandrosterone (DHEA) on fetal pulmonary circulation: An experimental study in pregnant sheep
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T08%3A16%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vasodilator%20effects%20of%20dehydroepiandrosterone%20(DHEA)%20on%20fetal%20pulmonary%20circulation:%20An%20experimental%20study%20in%20pregnant%20sheep&rft.jtitle=PloS%20one&rft.au=Sharma,%20Dyuti&rft.date=2018-06-27&rft.volume=13&rft.issue=6&rft.spage=e0198778&rft.pages=e0198778-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0198778&rft_dat=%3Cgale_plos_%3EA547840832%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c593t-f7cc2f53d6d17183de0f68d2ed8318d55efc7165d6a8f6731acd84847f6319803%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2060855402&rft_id=info:pmid/29949623&rft_galeid=A547840832&rfr_iscdi=true