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Is genetic fatherhood within reach for all azoospermic Klinefelter men?

Multidisciplinary management of Klinefelter cases is now considered good clinical practice in order to ensure optimal quality of life. Reproductive performance of Klinefelter men is an important issue however literature in this domain is limited and prone to bias. This was a retrospective longitudin...

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Published in:PloS one 2018-07, Vol.13 (7), p.e0200300-e0200300
Main Authors: Vloeberghs, Veerle, Verheyen, Greta, Santos-Ribeiro, Samuel, Staessen, Catherine, Verpoest, Willem, Gies, Inge, Tournaye, Herman
Format: Article
Language:English
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Summary:Multidisciplinary management of Klinefelter cases is now considered good clinical practice in order to ensure optimal quality of life. Reproductive performance of Klinefelter men is an important issue however literature in this domain is limited and prone to bias. This was a retrospective longitudinal cohort study performed at a tertiary referral University Centre for Reproductive Medicine and Genetics. One hundred thirty-eight non-mosaic azoospermic Klinefelter patients undergoing their first testicular biopsy (TESE) between 1994 and 2013, followed by intracytoplasmic sperm injection (ICSI) with fresh or frozen-thawed testicular sperm in the female partner, were followed-up longitudinally. The main outcome measure was cumulative live birth rate per Klinefelter patient embarking on TESE-ICSI. In forty-eight men (48/138) sperm were successfully retrieved at the first TESE (34.8%). The mean age of the patients was 32.4 years. Younger age at first TESE was associated with a higher sperm retrieval rate (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0200300