Lung cancer in idiopathic pulmonary fibrosis: A systematic review and meta-analysis

There are many epidemiological pieces of evidence that show IPF patients have the highest risk of lung cancer. We conducted a systematic review of all published data to define the characteristics of lung cancer that develops in IPF by performing a meta-analysis. This study was performed based on the...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2018-08, Vol.13 (8), p.e0202360-e0202360
Main Authors: JafariNezhad, AliReza, YektaKooshali, Mohammad Hossein
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Boolean algebra
Cancer
Care and treatment
Data search
Diagnosis
Epidemiology
Fibrosis
Geriatrics
Health risks
Humans
Idiopathic Pulmonary Fibrosis - epidemiology
Internal medicine
Lung cancer
Lung diseases
Lung Neoplasms - epidemiology
Medical ethics
Medical screening
Medicine
Medicine and Health Sciences
Meta-analysis
Mortality
Older people
Patients
Physical Sciences
Physiology
Pneumonia
Pulmonary fibrosis
Research and Analysis Methods
Risk factors
Science Policy
Smoking
Systematic review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c758t-26390ca7c98d8128a9096429f5280f1ff13566d7fc4ef5cf2a0ad1aa38f97f213
cites cdi_FETCH-LOGICAL-c758t-26390ca7c98d8128a9096429f5280f1ff13566d7fc4ef5cf2a0ad1aa38f97f213
container_end_page e0202360
container_issue 8
container_start_page e0202360
container_title PloS one
container_volume 13
creator JafariNezhad, AliReza
YektaKooshali, Mohammad Hossein
description There are many epidemiological pieces of evidence that show IPF patients have the highest risk of lung cancer. We conducted a systematic review of all published data to define the characteristics of lung cancer that develops in IPF by performing a meta-analysis. This study was performed based on the PRISMA guideline. Documents gathered by searching through the Web of Sciences, Scopus, PubMed/Medline, OVID, and COCHRANE databases which published before 03/25/2018 that related to lung cancer in IPFs' patients. Articles were searched using standard keywords as well as Mesh and Mesh Entry and all probabilistic combinations of words using Boolean operators. Data searching, extracting and quality appraising were done by two researchers, independently. At last, Random-effects size based on Cochrane test and I2 were used. The review protocol has been registered in PROSPERO with ID: CRD42018094037. Based on the meta-analysis conducted in 35 (0.18%) included studies, the total sample size of patients with IPF was estimated 131947 among whom 6384 had LC. The total rate of LC prevalence in IPF patients was estimated to be 13.54% (95% CI: 10.43-17.4) that was significantly 9 times higher in men vs. Women and smoker vs. non-smoker. Highest to lowest prevalence of cellular (histological) subtypes of lung cancer in IPF were SQCC (37.82%), ADC (30.79%), SmCC (20.48%), LCC (5.21%), and ADQC (4.81%), respectively. The highest and lowest stage of lung cancer in IPF patients was estimated at III and II, respectively. The highest involvement location of lung cancer in IPF patients was in the Peripheral. Also, the prevalence of the tumor region involved from the highest to the lowest was estimated to be in the RLL, LLL, RUL and LUL regions. Lung cancer in IPF, most commonly SQCC, presents in elderly heavy smokers with a male, locating in peripheral regions and the lower part of lung predominance.
doi_str_mv 10.1371/journal.pone.0202360
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2089279191</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A550451552</galeid><doaj_id>oai_doaj_org_article_05899cb1c3c5411a9b97ac94bdfa5ed8</doaj_id><sourcerecordid>A550451552</sourcerecordid><originalsourceid>FETCH-LOGICAL-c758t-26390ca7c98d8128a9096429f5280f1ff13566d7fc4ef5cf2a0ad1aa38f97f213</originalsourceid><addsrcrecordid>eNqNkl2L1DAUhoso7rr6D0QLgujFjPlo2sQLYVj8GBhYcNXbcCZNOhnaZEza1fn3ZpzuMpW9kFwknDznPTknb5Y9x2iOaYXfbf0QHLTznXd6jggitEQPsnMsKJmVBNGHJ-ez7EmMW4QY5WX5ODujCOOCUH6eXa8G1-QKnNIhty63tfU76DdW5buh7byDsM-NXQcfbXyfL_K4j73uoE9A0DdW_8rB1Xmne5hBes4-YU-zRwbaqJ-N-0X2_dPHb5dfZqurz8vLxWqmKsb7GSmpQAoqJXjNMeEgkCgLIgwjHBlsDKasLOvKqEIbpgwBBDUGoNyIyhBML7KXR91d66Mc5xElQVyQSmBxIJZHovawlbtgu9SO9GDl34APjYSQWmm1RIwLodZYUcUKjEGsRQVKFOvaANM1T1ofxmrDutO10q4P0E5EpzfObmTjb2SJBGMlSQJvRoHgfw469rKzUem2Baf9cHw3T7VJkdBX_6D3dzdSDaQGrDM-1VUHUblgDBUMM3YoO7-HSqvWnVXJPMam-CTh7SQhMb3-3TcwxCiX11__n736MWVfn7AbDW2_ib4deutdnILFEVTJdTFoczdkjOTB-7fTkAfvy9H7Ke3F6QfdJd2anf4BRx7-Nw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2089279191</pqid></control><display><type>article</type><title>Lung cancer in idiopathic pulmonary fibrosis: A systematic review and meta-analysis</title><source>Publicly Available Content (ProQuest)</source><source>PubMed Central</source><creator>JafariNezhad, AliReza ; YektaKooshali, Mohammad Hossein</creator><contributor>Roviello, Giandomenico</contributor><creatorcontrib>JafariNezhad, AliReza ; YektaKooshali, Mohammad Hossein ; Roviello, Giandomenico</creatorcontrib><description>There are many epidemiological pieces of evidence that show IPF patients have the highest risk of lung cancer. We conducted a systematic review of all published data to define the characteristics of lung cancer that develops in IPF by performing a meta-analysis. This study was performed based on the PRISMA guideline. Documents gathered by searching through the Web of Sciences, Scopus, PubMed/Medline, OVID, and COCHRANE databases which published before 03/25/2018 that related to lung cancer in IPFs' patients. Articles were searched using standard keywords as well as Mesh and Mesh Entry and all probabilistic combinations of words using Boolean operators. Data searching, extracting and quality appraising were done by two researchers, independently. At last, Random-effects size based on Cochrane test and I2 were used. The review protocol has been registered in PROSPERO with ID: CRD42018094037. Based on the meta-analysis conducted in 35 (0.18%) included studies, the total sample size of patients with IPF was estimated 131947 among whom 6384 had LC. The total rate of LC prevalence in IPF patients was estimated to be 13.54% (95% CI: 10.43-17.4) that was significantly 9 times higher in men vs. Women and smoker vs. non-smoker. Highest to lowest prevalence of cellular (histological) subtypes of lung cancer in IPF were SQCC (37.82%), ADC (30.79%), SmCC (20.48%), LCC (5.21%), and ADQC (4.81%), respectively. The highest and lowest stage of lung cancer in IPF patients was estimated at III and II, respectively. The highest involvement location of lung cancer in IPF patients was in the Peripheral. Also, the prevalence of the tumor region involved from the highest to the lowest was estimated to be in the RLL, LLL, RUL and LUL regions. Lung cancer in IPF, most commonly SQCC, presents in elderly heavy smokers with a male, locating in peripheral regions and the lower part of lung predominance.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0202360</identifier><identifier>PMID: 30114238</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Boolean algebra ; Cancer ; Care and treatment ; Data search ; Diagnosis ; Epidemiology ; Fibrosis ; Geriatrics ; Health risks ; Humans ; Idiopathic Pulmonary Fibrosis - epidemiology ; Internal medicine ; Lung cancer ; Lung diseases ; Lung Neoplasms - epidemiology ; Medical ethics ; Medical screening ; Medicine ; Medicine and Health Sciences ; Meta-analysis ; Mortality ; Older people ; Patients ; Physical Sciences ; Physiology ; Pneumonia ; Pulmonary fibrosis ; Research and Analysis Methods ; Risk factors ; Science Policy ; Smoking ; Systematic review</subject><ispartof>PloS one, 2018-08, Vol.13 (8), p.e0202360-e0202360</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 JafariNezhad, YektaKooshali. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 JafariNezhad, YektaKooshali 2018 JafariNezhad, YektaKooshali</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-26390ca7c98d8128a9096429f5280f1ff13566d7fc4ef5cf2a0ad1aa38f97f213</citedby><cites>FETCH-LOGICAL-c758t-26390ca7c98d8128a9096429f5280f1ff13566d7fc4ef5cf2a0ad1aa38f97f213</cites><orcidid>0000-0001-7339-8230</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2089279191/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2089279191?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30114238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Roviello, Giandomenico</contributor><creatorcontrib>JafariNezhad, AliReza</creatorcontrib><creatorcontrib>YektaKooshali, Mohammad Hossein</creatorcontrib><title>Lung cancer in idiopathic pulmonary fibrosis: A systematic review and meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>There are many epidemiological pieces of evidence that show IPF patients have the highest risk of lung cancer. We conducted a systematic review of all published data to define the characteristics of lung cancer that develops in IPF by performing a meta-analysis. This study was performed based on the PRISMA guideline. Documents gathered by searching through the Web of Sciences, Scopus, PubMed/Medline, OVID, and COCHRANE databases which published before 03/25/2018 that related to lung cancer in IPFs' patients. Articles were searched using standard keywords as well as Mesh and Mesh Entry and all probabilistic combinations of words using Boolean operators. Data searching, extracting and quality appraising were done by two researchers, independently. At last, Random-effects size based on Cochrane test and I2 were used. The review protocol has been registered in PROSPERO with ID: CRD42018094037. Based on the meta-analysis conducted in 35 (0.18%) included studies, the total sample size of patients with IPF was estimated 131947 among whom 6384 had LC. The total rate of LC prevalence in IPF patients was estimated to be 13.54% (95% CI: 10.43-17.4) that was significantly 9 times higher in men vs. Women and smoker vs. non-smoker. Highest to lowest prevalence of cellular (histological) subtypes of lung cancer in IPF were SQCC (37.82%), ADC (30.79%), SmCC (20.48%), LCC (5.21%), and ADQC (4.81%), respectively. The highest and lowest stage of lung cancer in IPF patients was estimated at III and II, respectively. The highest involvement location of lung cancer in IPF patients was in the Peripheral. Also, the prevalence of the tumor region involved from the highest to the lowest was estimated to be in the RLL, LLL, RUL and LUL regions. Lung cancer in IPF, most commonly SQCC, presents in elderly heavy smokers with a male, locating in peripheral regions and the lower part of lung predominance.</description><subject>Biology and Life Sciences</subject><subject>Boolean algebra</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Data search</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Fibrosis</subject><subject>Geriatrics</subject><subject>Health risks</subject><subject>Humans</subject><subject>Idiopathic Pulmonary Fibrosis - epidemiology</subject><subject>Internal medicine</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Medical ethics</subject><subject>Medical screening</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Mortality</subject><subject>Older people</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Physiology</subject><subject>Pneumonia</subject><subject>Pulmonary fibrosis</subject><subject>Research and Analysis Methods</subject><subject>Risk factors</subject><subject>Science Policy</subject><subject>Smoking</subject><subject>Systematic review</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QLgujFjPlo2sQLYVj8GBhYcNXbcCZNOhnaZEza1fn3ZpzuMpW9kFwknDznPTknb5Y9x2iOaYXfbf0QHLTznXd6jggitEQPsnMsKJmVBNGHJ-ez7EmMW4QY5WX5ODujCOOCUH6eXa8G1-QKnNIhty63tfU76DdW5buh7byDsM-NXQcfbXyfL_K4j73uoE9A0DdW_8rB1Xmne5hBes4-YU-zRwbaqJ-N-0X2_dPHb5dfZqurz8vLxWqmKsb7GSmpQAoqJXjNMeEgkCgLIgwjHBlsDKasLOvKqEIbpgwBBDUGoNyIyhBML7KXR91d66Mc5xElQVyQSmBxIJZHovawlbtgu9SO9GDl34APjYSQWmm1RIwLodZYUcUKjEGsRQVKFOvaANM1T1ofxmrDutO10q4P0E5EpzfObmTjb2SJBGMlSQJvRoHgfw469rKzUem2Baf9cHw3T7VJkdBX_6D3dzdSDaQGrDM-1VUHUblgDBUMM3YoO7-HSqvWnVXJPMam-CTh7SQhMb3-3TcwxCiX11__n736MWVfn7AbDW2_ib4deutdnILFEVTJdTFoczdkjOTB-7fTkAfvy9H7Ke3F6QfdJd2anf4BRx7-Nw</recordid><startdate>20180816</startdate><enddate>20180816</enddate><creator>JafariNezhad, AliReza</creator><creator>YektaKooshali, Mohammad Hossein</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7339-8230</orcidid></search><sort><creationdate>20180816</creationdate><title>Lung cancer in idiopathic pulmonary fibrosis: A systematic review and meta-analysis</title><author>JafariNezhad, AliReza ; YektaKooshali, Mohammad Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-26390ca7c98d8128a9096429f5280f1ff13566d7fc4ef5cf2a0ad1aa38f97f213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biology and Life Sciences</topic><topic>Boolean algebra</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Data search</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Fibrosis</topic><topic>Geriatrics</topic><topic>Health risks</topic><topic>Humans</topic><topic>Idiopathic Pulmonary Fibrosis - epidemiology</topic><topic>Internal medicine</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Medical ethics</topic><topic>Medical screening</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>Mortality</topic><topic>Older people</topic><topic>Patients</topic><topic>Physical Sciences</topic><topic>Physiology</topic><topic>Pneumonia</topic><topic>Pulmonary fibrosis</topic><topic>Research and Analysis Methods</topic><topic>Risk factors</topic><topic>Science Policy</topic><topic>Smoking</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JafariNezhad, AliReza</creatorcontrib><creatorcontrib>YektaKooshali, Mohammad Hossein</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Database‎ (1962 - current)</collection><collection>ProQuest Agricultural &amp; Environmental Science</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JafariNezhad, AliReza</au><au>YektaKooshali, Mohammad Hossein</au><au>Roviello, Giandomenico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung cancer in idiopathic pulmonary fibrosis: A systematic review and meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-08-16</date><risdate>2018</risdate><volume>13</volume><issue>8</issue><spage>e0202360</spage><epage>e0202360</epage><pages>e0202360-e0202360</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>There are many epidemiological pieces of evidence that show IPF patients have the highest risk of lung cancer. We conducted a systematic review of all published data to define the characteristics of lung cancer that develops in IPF by performing a meta-analysis. This study was performed based on the PRISMA guideline. Documents gathered by searching through the Web of Sciences, Scopus, PubMed/Medline, OVID, and COCHRANE databases which published before 03/25/2018 that related to lung cancer in IPFs' patients. Articles were searched using standard keywords as well as Mesh and Mesh Entry and all probabilistic combinations of words using Boolean operators. Data searching, extracting and quality appraising were done by two researchers, independently. At last, Random-effects size based on Cochrane test and I2 were used. The review protocol has been registered in PROSPERO with ID: CRD42018094037. Based on the meta-analysis conducted in 35 (0.18%) included studies, the total sample size of patients with IPF was estimated 131947 among whom 6384 had LC. The total rate of LC prevalence in IPF patients was estimated to be 13.54% (95% CI: 10.43-17.4) that was significantly 9 times higher in men vs. Women and smoker vs. non-smoker. Highest to lowest prevalence of cellular (histological) subtypes of lung cancer in IPF were SQCC (37.82%), ADC (30.79%), SmCC (20.48%), LCC (5.21%), and ADQC (4.81%), respectively. The highest and lowest stage of lung cancer in IPF patients was estimated at III and II, respectively. The highest involvement location of lung cancer in IPF patients was in the Peripheral. Also, the prevalence of the tumor region involved from the highest to the lowest was estimated to be in the RLL, LLL, RUL and LUL regions. Lung cancer in IPF, most commonly SQCC, presents in elderly heavy smokers with a male, locating in peripheral regions and the lower part of lung predominance.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30114238</pmid><doi>10.1371/journal.pone.0202360</doi><tpages>e0202360</tpages><orcidid>https://orcid.org/0000-0001-7339-8230</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2018-08, Vol.13 (8), p.e0202360-e0202360
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2089279191
source Publicly Available Content (ProQuest); PubMed Central
subjects Biology and Life Sciences
Boolean algebra
Cancer
Care and treatment
Data search
Diagnosis
Epidemiology
Fibrosis
Geriatrics
Health risks
Humans
Idiopathic Pulmonary Fibrosis - epidemiology
Internal medicine
Lung cancer
Lung diseases
Lung Neoplasms - epidemiology
Medical ethics
Medical screening
Medicine
Medicine and Health Sciences
Meta-analysis
Mortality
Older people
Patients
Physical Sciences
Physiology
Pneumonia
Pulmonary fibrosis
Research and Analysis Methods
Risk factors
Science Policy
Smoking
Systematic review
title Lung cancer in idiopathic pulmonary fibrosis: A systematic review and meta-analysis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T23%3A19%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lung%20cancer%20in%20idiopathic%20pulmonary%20fibrosis:%20A%20systematic%20review%20and%20meta-analysis&rft.jtitle=PloS%20one&rft.au=JafariNezhad,%20AliReza&rft.date=2018-08-16&rft.volume=13&rft.issue=8&rft.spage=e0202360&rft.epage=e0202360&rft.pages=e0202360-e0202360&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0202360&rft_dat=%3Cgale_plos_%3EA550451552%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c758t-26390ca7c98d8128a9096429f5280f1ff13566d7fc4ef5cf2a0ad1aa38f97f213%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2089279191&rft_id=info:pmid/30114238&rft_galeid=A550451552&rfr_iscdi=true