Progression of cardiac allograft vasculopathy assessed by serial three-vessel quantitative coronary angiography

The purpose of the present study was to assess the short- and long-term progression of cardiac allograft vasculopathy (CAV) using serial 3-vessel quantitative coronary angiography (QCA). CAV progression was assessed using serial 3-vessel QCA analysis at baseline, 1-year and long-term angiographic fo...

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Bibliographic Details
Published in:PloS one 2018-08, Vol.13 (8), p.e0202950-e0202950
Main Authors: Zanchin, Christian, Yamaji, Kyohei, Rogge, Carolin, Lesche, Dorothea, Zanchin, Thomas, Ueki, Yasushi, Windecker, Stephan, Mohacsi, Paul, Räber, Lorenz, Sigurdardottir, Vilborg
Format: Article
Language:English
Subjects:
Adult
Allografts
Angiography
Atherosclerosis
Biology and Life Sciences
Calcium channels (voltage-gated)
Cardiac Imaging Techniques - methods
Cardiology
Cardiovascular disease
Continuity of Patient Care
Coronary angiography
Coronary Angiography - methods
Coronary heart disease
Coronary vessels
Cytomegalovirus
Development and progression
Disease Progression
Female
Graft Occlusion, Vascular - diagnostic imaging
Graft Occlusion, Vascular - etiology
Graft Rejection - etiology
Graft Rejection - prevention & control
Health aspects
Heart
Heart Diseases - surgery
Heart transplantation
Heart Transplantation - adverse effects
Humans
Immunosuppressive agents
Male
Medical imaging
Medicine and Health Sciences
Middle Aged
Mortality
Patient outcomes
Patients
Postoperative Complications - diagnostic imaging
Reduction
Research and Analysis Methods
Retrospective Studies
Risk Assessment
Risk factors
Segments
Stenosis
Stents
Studies
Transplantation
Transplants & implants
Ultrasonic imaging
Vascular diseases
Vascular Diseases - diagnostic imaging
Vascular Diseases - etiology
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Summary:The purpose of the present study was to assess the short- and long-term progression of cardiac allograft vasculopathy (CAV) using serial 3-vessel quantitative coronary angiography (QCA). CAV progression was assessed using serial 3-vessel QCA analysis at baseline, 1-year and long-term angiographic follow-up (8.5±3.7 years) after heart transplantation. The change in minimal lumen diameter (MLD) and percent diameter stenosis (%DS) was serially assessed within matched segments. Patients were graded according to the ISHLT-CAV classification and grouped as ISHLT-CAV0 and ISHLT-CAV1-3. The primary endpoint was mean change in MLD and %DS. A total of 41 patients and 520 matched segments were available for serial 3-vessel QCA. Overall, MLD decreased non-significantly from baseline to 1-year follow-up and significantly from 1-year to the long-term angiographic follow-up (Δ-0.08mm/year [95%CI -0.11 to -0.05], P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0202950