Vitamin K enhances the production of brain sulfatides during remyelination

Multiple sclerosis (MS) is a devastating neurological disease, which is characterized by multifocal demyelinating lesions in the central nervous system. The most abundant myelin lipids are galactosylceramides and their sulfated form, sulfatides, which together account for about 27% of the total dry...

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Bibliographic Details
Published in:PloS one 2018-08, Vol.13 (8), p.e0203057-e0203057
Main Authors: Popescu, Daniela C, Huang, He, Singhal, Naveen K, Shriver, Leah, McDonough, Jennifer, Clements, Robert J, Freeman, Ernest J
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Brain
Central nervous system
Coagulation
Copper
Cuprizone
Demyelination
Diet
Glycolipids
Health aspects
Laboratories
Lesions
Lipids
Medicine and Health Sciences
Metabolism
Mice
Multiple sclerosis
Myelin
Myelination
Nutrition research
Phylloquinone
Physical sciences
Physiological aspects
Properties
Risk factors
Rodents
Synergistic effect
Vitamin D
Vitamin K
Vitamins
Weight
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Summary:Multiple sclerosis (MS) is a devastating neurological disease, which is characterized by multifocal demyelinating lesions in the central nervous system. The most abundant myelin lipids are galactosylceramides and their sulfated form, sulfatides, which together account for about 27% of the total dry weight of myelin. In this study we investigated the role of vitamin K in remyelination, by using an animal model for MS, the cuprizone model. Demyelination was induced in C57Bl6/J mice, by feeding them a special diet containing 0.3% cuprizone (w/w) for 6 weeks. After 6 weeks, cuprizone was removed from the diet and mice were allowed to remyelinate for either 1 or 3 weeks, in the absence or presence of vitamin K (i.p. phylloquinone, 2mg, three times per week). Vitamin K enhanced the production of total brain sulfatides, after both 1 week and 3 weeks of remyelination (n = 5, P-values were
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0203057