Chinese herbal medicine reduced the risk of stroke in patients with Parkinson's disease: A population-based retrospective cohort study from Taiwan

Parkinson's disease (PD) is associated with a significantly increased risk of stroke. Traditional Chinese medicine (TCM) has long been used in Asia to treat stroke, but there are no large-scale clinical data to confirm its efficacy in protecting PD patients against stroke. Herein, we analyzed a...

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Bibliographic Details
Published in:PloS one 2018-09, Vol.13 (9), p.e0203473-e0203473
Main Authors: Lai, Ching-Yuan, Chiang, Jen-Huan, Lin, Jaung-Geng, Yen, Hung-Rong, Tu, Cheng-Hao, Chen, Yi-Hung
Format: Article
Language:English
Subjects:
Acupuncture
Aged
Aged, 80 and over
Biology and Life Sciences
Care and treatment
Chinese herbal medicine
Chinese medicine
Clinical trials
Cohort analysis
Comorbidity
Complications and side effects
Confidence intervals
Constipation
Diabetes
Drugs, Chinese Herbal - therapeutic use
Emergency medical care
Female
Gender
Health insurance
Health risks
Herbal medicine
Hospitals
Humans
Hypertension
Incidence
Kaplan-Meier Estimate
Male
Medicine
Medicine and Health Sciences
Medicine, Chinese Traditional - methods
Medicine, Chinese Traditional - statistics & numerical data
Middle Aged
Mortality
Movement disorders
Neurodegenerative diseases
Parkinson disease
Parkinson Disease - epidemiology
Parkinson Disease - prevention & control
Parkinson's disease
Patients
Population
Population studies
Population Surveillance - methods
Population-based studies
Prevention
Proportional Hazards Models
Retrospective Studies
Risk
Risk Factors
Social Sciences
Statistical analysis
Statistical models
Stroke
Stroke - epidemiology
Stroke - prevention & control
Studies
Substance abuse treatment
Systematic review
Taiwan - epidemiology
Traditional Chinese medicine
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Summary:Parkinson's disease (PD) is associated with a significantly increased risk of stroke. Traditional Chinese medicine (TCM) has long been used in Asia to treat stroke, but there are no large-scale clinical data to confirm its efficacy in protecting PD patients against stroke. Herein, we analyzed a cohort of 1,000,000 records from Taiwan's National Health Insurance Research Database for the period 1997-2011, and identified 1,882 patients with new-onset PD. We matched 290 patients who received Chinese herbal medicine (CHM) by age, sex, year of CHM prescription, and year of PD diagnosis with 290 patients who did not use CHM as control. Both cohorts were followed until the end of 2013 for the incidence of new-onset stroke. In a multivariable Cox proportional hazard model adjusted for potential comorbidities, the incidence of stroke was lower among PD patients using CHM compared with non-CHM users (11.10 per 100 person-years vs 23.15 per 100 person-years; Hazard ratio: 0.56; 95% confidence interval:  0.44 to 0.72). The probability curve generated from our follow-up data showed that PD patients receiving CHM treatment had a decreased risk of stroke compared with those not receiving CHM treatment (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0203473