The effect of exposure to high altitude and low oxygen on intestinal microbial communities in mice

This experiment was conducted to investigate the effect of exposure to high altitude and low oxygen on intestinal microbial communities using mice as an animal model. Fecal microbiota from mice housed in a control environment representing 2,200 meters (NC group) above sea level with 16% Oxygen and m...

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Bibliographic Details
Published in:PloS one 2018-09, Vol.13 (9), p.e0203701-e0203701
Main Authors: Zhang, Wei, Jiao, Lefei, Liu, Ruixin, Zhang, Yu, Ji, Qiaorong, Zhang, Huan, Gao, Xiang, Ma, Yan, Shi, Hai Ning
Format: Article
Language:English
Subjects:
Abundance
Altitude
Altitude effects
Altitude sickness
Animals
Arachidonic acid
Bacteria - genetics
Bacteria - isolation & purification
Biofilms
Biology and Life Sciences
Biosynthesis
Carbohydrates
Chronic fatigue syndrome
Communities
Energy metabolism
Exposure
Fecal microflora
Feces - microbiology
Female
Functional analysis
Gastrointestinal Microbiome - physiology
Health aspects
Hematocrit
Hemoglobins - analysis
High altitude
High-altitude environments
High-Throughput Nucleotide Sequencing
Hospitals
Hypoxia
Immunology
Intestine
Laboratory animals
Measuring instruments
Medicine
Medicine and Health Sciences
Metabolic Networks and Pathways - genetics
Metabolic pathways
Metabolism
Metabolites
Mice
Mice, Inbred BALB C
Microbial activity
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Motility
Oxygen
Phenotype
Physical Sciences
Physiological aspects
Physiology
Relative abundance
Research and Analysis Methods
RNA, Ribosomal, 16S - chemistry
RNA, Ribosomal, 16S - genetics
RNA, Ribosomal, 16S - metabolism
Sea level
Sequence Analysis, DNA
Signal transduction
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Description
Summary:This experiment was conducted to investigate the effect of exposure to high altitude and low oxygen on intestinal microbial communities using mice as an animal model. Fecal microbiota from mice housed in a control environment representing 2,200 meters (NC group) above sea level with 16% Oxygen and mice that were placed in a hypobaric chamber representing 5000 meters (HC group) above sea level with 11% Oxygen for 30 days, were analyzed by the HiSeq Illumina sequencing platform. The results showed a significant difference in beta diversity observed between the two groups, while no significant difference was observed in alpha diversity. Compared with the NC group, the relative abundance of class Epsilonproteobacteria, phlym Actinobacteria, class Erysipelotrichia and genus Helicobacter were significantly lower (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0203701