Chronic kidney disease (CKD) patients are exposed to more proton pump inhibitor (PPI)s compared to non-CKD patients

Proton pump inhibitor use is associated with incident chronic kidney disease, chronic kidney disease progression and end-stage renal disease. However, the extent of proton pump inhibitor prescriptions to chronic kidney disease patients is still unclear. In a retrospective study, we enrolled patients...

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Bibliographic Details
Published in:PloS one 2018-09, Vol.13 (9), p.e0203878-e0203878
Main Authors: Lee, Hee Jeong, Lee, Haekyung, Oh, Song Hee, Park, Joonbyung, Park, Suyeon, Jeon, Jin Seok, Noh, HyunJin, Han, Dong Cheol, Kwon, Soon Hyo
Format: Article
Language:English
Subjects:
Anticoagulants
Biology and Life Sciences
Cardiology
Cardiovascular disease
Chronic illnesses
Drug dosages
End-stage renal disease
Epidermal growth factor receptors
Females
Gastroenterology
Gastroesophageal reflux
Glomerular filtration rate
Health care facilities
Hospitals
Inhibitors
Internal medicine
Kidney diseases
Kidneys
Laboratories
Medical electronics
Medical personnel
Medical records
Medicine
Medicine and Health Sciences
Mortality
Nephrology
Neurology
Patients
People and Places
Physicians
Prescriptions
Proton pump inhibitors
Protons
Risk groups
Studies
Ulcers
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Summary:Proton pump inhibitor use is associated with incident chronic kidney disease, chronic kidney disease progression and end-stage renal disease. However, the extent of proton pump inhibitor prescriptions to chronic kidney disease patients is still unclear. In a retrospective study, we enrolled patients (>18 years old) who received proton pump inhibitor in the out-patient setting from 2014 through 2015. All data was obtained from electronical medical records of Soonchunhyang Medical Center. The prescription patterns and characteristics of proton pump inhibitors were analyzed according to individual estimated glomerular filtration rate of the patients. During the study period 178,228 patients visited the out-patient clinic. Proton pump inhibitors were prescribed to 9,109 (5.11%) patients. In our sample, 50% were females and 9.8% were chronic kidney disease (eGFR
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0203878