Dual biomarkers long non-coding RNA GAS5 and microRNA-34a co-expression signature in common solid tumors

Accumulating evidence indicates that non-coding RNAs including microRNAs (miRs) and long non-coding RNAs (lncRNAs) are aberrantly expressed in cancer, providing promising biomarkers for diagnosis, prognosis and/or therapeutic targets. We aimed in the current work to quantify the expression profile o...

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Bibliographic Details
Published in:PloS one 2018-10, Vol.13 (10), p.e0198231-e0198231
Main Authors: Toraih, Eman A, Alghamdi, Saleh Ali, El-Wazir, Aya, Hosny, Marwa M, Hussein, Mohammad H, Khashana, Moataz S, Fawzy, Manal S
Format: Article
Language:English
Subjects:
Binding sites
Biochemistry
Bioinformatics
Biological markers
Biology and life sciences
Biomarkers
Brain cancer
Cancer
Cancer research
Cell growth
Cluster analysis
Clustering
Gene expression
Genes
Genetic aspects
Genetics
Genomes
Glioblastoma
Hepatocellular carcinoma
Histology
Kidney cancer
Liver cancer
Medical prognosis
Medicine
Medicine and Health Sciences
MicroRNA
MicroRNAs
miRNA
Molecular biology
Non-coding RNA
Pathogenesis
Patients
Polymerase chain reaction
Renal cell carcinoma
Research and Analysis Methods
Ribonucleic acid
RNA
Solid tumors
Therapeutic applications
Tumor suppressor genes
Tumorigenesis
Tumors
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Summary:Accumulating evidence indicates that non-coding RNAs including microRNAs (miRs) and long non-coding RNAs (lncRNAs) are aberrantly expressed in cancer, providing promising biomarkers for diagnosis, prognosis and/or therapeutic targets. We aimed in the current work to quantify the expression profile of miR-34a and one of its bioinformatically selected partner lncRNA growth arrest-specific 5 (GAS5) in a sample of Egyptian cancer patients, including three prevalent types of cancer in our region; renal cell carcinoma (RCC), glioblastoma (GB), and hepatocellular carcinoma (HCC) as well as to correlate these expression profiles with the available clinicopathological data in an attempt to clarify their roles in cancer. Quantitative real-time polymerase chain reaction analysis was applied. Different bioinformatics databases were searched to confirm the potential miRNAs-lncRNA interactions of the selected ncRNAs in cancer pathogenesis. The tumor suppressor lncRNA GAS5 was significantly under-expressed in the three types of cancer [0.08 (0.006-0.38) in RCC, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0198231