Somatosensory and transcranial motor evoked potential monitoring in a porcine model for experimental procedures

Evoked potential monitoring has evolved as an essential tool not only for elaborate neurological diagnostics, but also for general clinical practice. Moreover, it is increasingly used to guide surgical procedures and prognosticate neurological outcome in the critical care unit, e.g. after cardiac ar...

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Published in:PloS one 2018-10, Vol.13 (10), p.e0205410-e0205410
Main Authors: Maier, Sven, Goebel, Ulrich, Krause, Sonja, Benk, Christoph, Schick, Martin A, Buerkle, Hartmut, Beyersdorf, Friedhelm, Kari, Fabian A, Wollborn, Jakob
Format: Article
Language:English
Subjects:
Analysis
Anesthesiology
Animal experimentation
Animal models
Biology and Life Sciences
Cardiovascular system
Care and treatment
Computer simulation
Critical care
Diagnosis
Electrodes
Evoked potentials
Experiments
Heart surgery
Hogs
Innovations
Ischemia
Laboratory animals
Medical innovations
Medical research
Medicine
Medicine and Health Sciences
Monitoring
Motor evoked potentials
Nervous system diseases
Neurosurgery
Physical Sciences
Prognosis
Research and Analysis Methods
Spinal cord
Surgery
Surgical instruments
Swine
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cited_by cdi_FETCH-LOGICAL-c692t-2213d72b7cb50a27e20514a920ea6ccf49f9e9b21ca06e9ebbdd0e08717da1453
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Krause, Sonja
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Schick, Martin A
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Wollborn, Jakob
description Evoked potential monitoring has evolved as an essential tool not only for elaborate neurological diagnostics, but also for general clinical practice. Moreover, it is increasingly used to guide surgical procedures and prognosticate neurological outcome in the critical care unit, e.g. after cardiac arrest. Experimental animal models aim to simulate a human-like scenario to deduct relevant clinical information for patient treatment and to test novel therapeutic opportunities. Porcine models are particularly ideal due to a comparable cardiovascular system and size. However, certain anatomic disparities have to be taken into consideration when evoked potential monitoring is used in animal models. We describe a non-invasive and reproducible set-up useful for different modalities in porcine models. We further illustrate hints to overcome multi-faceted problems commonly occurring while using this sophisticated technique. Our descriptions can be used to answer a plethora of experimental questions, and help to further facilitate experimental therapeutic innovation.
doi_str_mv 10.1371/journal.pone.0205410
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subjects Analysis
Anesthesiology
Animal experimentation
Animal models
Biology and Life Sciences
Cardiovascular system
Care and treatment
Computer simulation
Critical care
Diagnosis
Electrodes
Evoked potentials
Experiments
Heart surgery
Hogs
Innovations
Ischemia
Laboratory animals
Medical innovations
Medical research
Medicine
Medicine and Health Sciences
Monitoring
Motor evoked potentials
Nervous system diseases
Neurosurgery
Physical Sciences
Prognosis
Research and Analysis Methods
Spinal cord
Surgery
Surgical instruments
Swine
title Somatosensory and transcranial motor evoked potential monitoring in a porcine model for experimental procedures
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