Elevated circulating tumor cells and squamous cell carcinoma antigen levels predict poor survival for patients with locally advanced cervical cancer treated with radiotherapy

To evaluate the prognostic effects of combining serum circulating tumor cells (CTCs) and squamous cell carcinoma antigen (SCC-Ag) levels on patients with locally advanced cervical cancer treated with radiotherapy. Ninety-nine patients with locally advanced cervical cancer ([FIGO] stage IIB-IVA) unde...

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Published in:PloS one 2018-10, Vol.13 (10), p.e0204334-e0204334
Main Authors: Wen, Yue-Feng, Cheng, Tian-Tian, Chen, Xiao-Long, Huang, Wen-Jin, Peng, Hai-Hua, Zhou, Tong-Chong, Lin, Xiao-Dan, Zeng, Li-Si
Format: Article
Language:English
Subjects:
Analysis
Antigens
Bioindicators
Biology and Life Sciences
Biomarkers
Breast cancer
Cancer
Cancer cells
Cancer therapies
Care and treatment
Cell survival
Cervical cancer
Cervix
Chemoradiotherapy
Clinical medicine
Colorectal cancer
Development and progression
Hazards
Health risks
Hospitals
Lung cancer
Lymphatic system
Medical prognosis
Medicine and Health Sciences
Metastasis
Multivariate analysis
NMR
Nuclear magnetic resonance
Parameter identification
Patients
Physical Sciences
Predictions
Radiation therapy
Radiotherapy
Regression analysis
Regression models
Research and Analysis Methods
Squamous cell carcinoma
Survival
Treatment outcome
Tumor cells
Tumors
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cited_by cdi_FETCH-LOGICAL-c692t-fc15207f0f1d778522233bfe95a62fa34969c1338e1889ee92585988e38837873
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container_issue 10
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creator Wen, Yue-Feng
Cheng, Tian-Tian
Chen, Xiao-Long
Huang, Wen-Jin
Peng, Hai-Hua
Zhou, Tong-Chong
Lin, Xiao-Dan
Zeng, Li-Si
description To evaluate the prognostic effects of combining serum circulating tumor cells (CTCs) and squamous cell carcinoma antigen (SCC-Ag) levels on patients with locally advanced cervical cancer treated with radiotherapy. Ninety-nine patients with locally advanced cervical cancer ([FIGO] stage IIB-IVA) undergoing radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) were identified. The association between serum CTC level and clinicopathological parameters was examined. Univariate and multivariate survival analyses were performed by using Cox's proportional hazards regression model. Elevated CTC and SCC-Ag levels were significantly associated with poor disease-free survival (DFS). Multivariate analysis suggest that serum CTC level, FIGO stage and serum SCC-Ag level were independent prognostic factors for two-year DFS. When CTC and SCC-Ag levels were combined into a new risk model to predict disease progression of cervical cancer patients, it performed a significantly better predictive efficiency compared with either biomarker alone. Serum CTC and SCC-Ag levels are potentially useful biomarkers for prediction of prognosis in locally advanced cervical cancer patients and their combination significantly improves predictive ability for survival in locally advanced cervical cancer patients.
doi_str_mv 10.1371/journal.pone.0204334
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Ninety-nine patients with locally advanced cervical cancer ([FIGO] stage IIB-IVA) undergoing radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) were identified. The association between serum CTC level and clinicopathological parameters was examined. Univariate and multivariate survival analyses were performed by using Cox's proportional hazards regression model. Elevated CTC and SCC-Ag levels were significantly associated with poor disease-free survival (DFS). Multivariate analysis suggest that serum CTC level, FIGO stage and serum SCC-Ag level were independent prognostic factors for two-year DFS. When CTC and SCC-Ag levels were combined into a new risk model to predict disease progression of cervical cancer patients, it performed a significantly better predictive efficiency compared with either biomarker alone. 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Ninety-nine patients with locally advanced cervical cancer ([FIGO] stage IIB-IVA) undergoing radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) were identified. The association between serum CTC level and clinicopathological parameters was examined. Univariate and multivariate survival analyses were performed by using Cox's proportional hazards regression model. Elevated CTC and SCC-Ag levels were significantly associated with poor disease-free survival (DFS). Multivariate analysis suggest that serum CTC level, FIGO stage and serum SCC-Ag level were independent prognostic factors for two-year DFS. When CTC and SCC-Ag levels were combined into a new risk model to predict disease progression of cervical cancer patients, it performed a significantly better predictive efficiency compared with either biomarker alone. Serum CTC and SCC-Ag levels are potentially useful biomarkers for prediction of prognosis in locally advanced cervical cancer patients and their combination significantly improves predictive ability for survival in locally advanced cervical cancer patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30303986</pmid><doi>10.1371/journal.pone.0204334</doi><tpages>e0204334</tpages><orcidid>https://orcid.org/0000-0001-6039-8805</orcidid><oa>free_for_read</oa></addata></record>
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subjects Analysis
Antigens
Bioindicators
Biology and Life Sciences
Biomarkers
Breast cancer
Cancer
Cancer cells
Cancer therapies
Care and treatment
Cell survival
Cervical cancer
Cervix
Chemoradiotherapy
Clinical medicine
Colorectal cancer
Development and progression
Hazards
Health risks
Hospitals
Lung cancer
Lymphatic system
Medical prognosis
Medicine and Health Sciences
Metastasis
Multivariate analysis
NMR
Nuclear magnetic resonance
Parameter identification
Patients
Physical Sciences
Predictions
Radiation therapy
Radiotherapy
Regression analysis
Regression models
Research and Analysis Methods
Squamous cell carcinoma
Survival
Treatment outcome
Tumor cells
Tumors
title Elevated circulating tumor cells and squamous cell carcinoma antigen levels predict poor survival for patients with locally advanced cervical cancer treated with radiotherapy
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