Seroprevalence of fourteen human polyomaviruses determined in blood donors

The polyomavirus family currently includes thirteen human polyomavirus (HPyV) species. In immunocompromised and elderly persons HPyVs are known to cause disease, such as progressive multifocal leukoencephalopathy (JCPyV), haemorrhagic cystitis and nephropathy (BKPyV), Merkel cell carcinoma (MCPyV),...

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Bibliographic Details
Published in:PloS one 2018-10, Vol.13 (10), p.e0206273-e0206273
Main Authors: Kamminga, Sergio, van der Meijden, Els, Feltkamp, Mariet C W, Zaaijer, Hans L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Analysis
Antibodies, Viral - blood
Biology and life sciences
Blood
Blood & organ donations
Blood donation
Blood Donors
Cystitis
Disease
Female
Geriatrics
Humans
Immunoassay
Immunocompromised hosts
Immunoglobulin G - blood
Infections
Leukoencephalopathy
Male
Medicine and Health Sciences
Middle Aged
Multiple sclerosis
Nephropathy
Netherlands - epidemiology
Older people
Papillomavirus infections
People and places
Polyomavirus - immunology
Polyomavirus Infections - diagnosis
Polyomavirus Infections - epidemiology
Polyomavirus Infections - virology
Population
Prevalence
Prevalence studies (Epidemiology)
Progressive multifocal leukoencephalopathy
Proteins
Research and Analysis Methods
Risk factors
Serology
Transplants & implants
Tropism
Viruses
Young Adult
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Summary:The polyomavirus family currently includes thirteen human polyomavirus (HPyV) species. In immunocompromised and elderly persons HPyVs are known to cause disease, such as progressive multifocal leukoencephalopathy (JCPyV), haemorrhagic cystitis and nephropathy (BKPyV), Merkel cell carcinoma (MCPyV), and trichodysplasia spinulosa (TSPyV). Some recently discovered polyomaviruses are of still unknown prevalence and pathogenic potential. Because HPyVs infections persist and might be transferred by blood components to immunocompromised patients, we studied the seroprevalence of fourteen polyomaviruses in adult Dutch blood donors. For most polyomaviruses the observed seroprevalence was high (60-100%), sometimes slightly increasing or decreasing with age. Seroreactivity increased with age for JCPyV, HPyV6 and HPyV7 and decreased for BKPyV and TSPyV. The most recently identified polyomaviruses HPyV12, NJPyV and LIPyV showed low overall seroprevalence (~5%) and low seroreactivity, questioning their human tropism. Altogether, HPyV infections are common in Dutch blood donors, with an average of nine polyomaviruses per subject.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0206273