Developing a panel of biomarkers and miRNA in patients with myocardial infarction for early intervention strategies of heart failure in West Virginian population

Myocardial infarction is the most common cause of heart failure. MI has been intricately linked to ventricular remodeling, subsequently leading to the reduction in the cardiac ejection fraction causing HF. The cumulative line of evidence suggests an important role of several biomarkers in modulating...

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Bibliographic Details
Published in:PloS one 2018-10, Vol.13 (10), p.e0205329-e0205329
Main Authors: Lakhani, Hari Vishal, Khanal, Tilak, Gabi, Alaa, Yousef, George, Alam, Mian Bilal, Sharma, Dana, Aljoudi, Haytham, Puri, Nitin, Thompson, Ellen, Shapiro, Joseph I, Sodhi, Komal
Format: Article
Language:English
Subjects:
Bioindicators
Biological markers
Biology and Life Sciences
Biomarkers
Cardiology
Care and treatment
Complications
Correlation
Correlation analysis
Cytokines
Echocardiography
Gelatinase B
Health aspects
Heart
Heart attack
Heart attacks
Heart diseases
Heart failure
Incidence
Interleukin 10
Interleukin 6
Internal medicine
Intervention
Medicine
Medicine and Health Sciences
Methods
MicroRNA
MicroRNAs
miRNA
Mortality
Myocardial infarction
Patients
Research and Analysis Methods
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Ventricle
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Summary:Myocardial infarction is the most common cause of heart failure. MI has been intricately linked to ventricular remodeling, subsequently leading to the reduction in the cardiac ejection fraction causing HF. The cumulative line of evidence suggests an important role of several biomarkers in modulating the cardiac vasculature, further contributing towards the progression of post-MI complications. Studies have demonstrated, yet not fully established, that an important biomarker, IL-10, has a causal relationship with MI and associated cardiac dysfunction. This study aims to establish the role of IL-10 as a prognostic marker for the cardiovascular outcomes and to develop a panel of biomarkers and circulating miRNAs that could potentially result in the early detection of HF resulting from MI, allowing for early intervention strategies. Blood was withdrawn and echocardiography assessment was performed on a total of 43 patients that were enrolled, within 24 hours of the incidence of MI. Patients were divided in three main groups, based on the ejection fraction measurement from echocardiography: control (n = 14), MI with normal EF (MI+NEF, n = 13) and MI with low EF (MI+LEF, n = 16). Our results showed that TGFβ-1, TNF-α, IL-6 and MMP-9 were upregulated significantly in MI+NEF group and more so in MI+LEF group, as compared to control group (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0205329