Correlation between image characteristics and pathologic findings in non small cell lung cancer patients after anatomic resection

Tumor characteristics in computed tomography (CT) are correlated to pathologic presentation and survival. However, most studies have been based on thin slice thickness CT while lymph node metastatic pattern has remained unclear. The aim of this study was to analyze the correlation between image char...

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Bibliographic Details
Published in:PloS one 2018-10, Vol.13 (10), p.e0206386-e0206386
Main Authors: Fu, Jui-Ying, Wan, Yung-Liang, Huang, Tzu-Yen, Wu, Ching-Feng, Liu, Yun-Hen, Hsieh, Ming-Ju, Wu, Yi-Cheng, Wu, Ching-Yang
Format: Article
Language:English
Subjects:
Adenocarcinoma
Biology and Life Sciences
Biopsy
Cancer
Cancer therapies
Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - surgery
Clinical medicine
Computed tomography
Consolidation
Correlation
Correlation analysis
Dissection
Female
Heart surgery
Hospitals
Humans
Impact analysis
Infiltration
Lesions
Lung cancer
Lung diseases
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Lymph nodes
Lymphatic Metastasis
Lymphatic system
Male
Medical imaging
Medical prognosis
Medical records
Medicine and Health Sciences
Metastases
Middle Aged
Necrosis
Neoplasm Staging
NMR
Nodes
Noise
Nuclear magnetic resonance
Pathology
Patients
Pleura
Prognosis
Research and Analysis Methods
Retrospective Studies
Survival
Survival Analysis
Thorax
Tomography
Tomography, X-Ray Computed
Tumor Burden
Tumors
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Summary:Tumor characteristics in computed tomography (CT) are correlated to pathologic presentation and survival. However, most studies have been based on thin slice thickness CT while lymph node metastatic pattern has remained unclear. The aim of this study was to analyze the correlation between image characteristics under 5 mm slice thickness and pathology findings in non small lung cancer patients who have received curative resection. From January 2010 to May 2014, 440 patients who underwent curative resection were included and medical records were reviewed retrospectively. The tumor size and consolidation tumor ratio were simultaneously evaluated and measured by a physician, a thoracic surgeon, and a radiologist. The correlation between image and pathology characteristics and its survival impact was analyzed. Tumor sizes, as measured by CT and by pathologic measurement were highly coincident. (p < 0.001) GGO predominant lesions were correlated to well-differentiated adenocarcinoma, (p< 0.001), and less tumor necrosis (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0206386