HFE hemochromatosis screening in patients with severe hip osteoarthritis: A prospective cross-sectional study

Despite the high frequency of HFE gene mutations in Western Europe, widespread screening for HFE hemochromatosis is not recommended due to its variable phenotype. Joint pain and a premature osteoarthritis-like disease including the hip joints are the most frequent manifestation in patients with HFE...

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Bibliographic Details
Published in:PloS one 2018-11, Vol.13 (11), p.e0207415-e0207415
Main Authors: Oppl, Bastian, Husar-Memmer, Emma, Pfefferkorn, Svea, Blank, Martha, Zenz, Peter, Gollob, Eva, Wurnig, Christian, Engel, Alfred, Stadlmayr, Andreas, Uyanik, Gökhan, Brozek, Wolfgang, Klaushofer, Klaus, Zwerina, Jochen, Datz, Christian
Format: Article
Language:English
Subjects:
Aged
Arthritis
Arthroplasty, Replacement - methods
Biocompatibility
Biology and Life Sciences
Boltzmann, Ludwig Eduard (1844-1906)
Bombast von Hohenheim, Philippus Aureolus Theophrastus (Paracelsus) (1493-1541)
Bone surgery
Cross-sectional studies
Deoxyribonucleic acid
DNA
Female
Ferritin
Ferritins - blood
Genetic testing
Genotype
Hemochromatosis
Hemochromatosis - complications
Hemochromatosis - diagnosis
Hemochromatosis - physiopathology
Hemochromatosis - surgery
Hemochromatosis Protein - genetics
Hepatology
HFE protein
Hip
Homozygosity
Humans
Identification methods
Internal medicine
Iron
Iron Overload - complications
Iron Overload - diagnosis
Iron Overload - physiopathology
Joint replacement surgery
Liver cirrhosis
Male
Medical screening
Medicine and Health Sciences
Middle Aged
Mutation
Osteoarthritis
Osteoarthritis, Hip - complications
Osteoarthritis, Hip - diagnosis
Osteoarthritis, Hip - physiopathology
Osteoarthritis, Hip - surgery
Pain
Patients
Phenotypes
Risk factors
Screening
Severity of Illness Index
Surgery
Transferrin
Transferrins
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Summary:Despite the high frequency of HFE gene mutations in Western Europe, widespread screening for HFE hemochromatosis is not recommended due to its variable phenotype. Joint pain and a premature osteoarthritis-like disease including the hip joints are the most frequent manifestation in patients with HFE hemochromatosis and iron overload. Therefore, screening of patients with severe osteoarthritis of the hip could identify patients with HFE hemochromatosis. In this prospective cross-sectional study, 940 patients aged
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0207415