One-year weight management lowers lipopolysaccharide-binding protein and its implication in metainflammation and liver fibrosis

Studies showed that the endotoxemia-related biomarker, lipopolysaccharide-binding protein (LBP), is associated with obesity and fatty liver. The level of LBP is reduced after surgical weight loss. This study aimed to verify the change of serum LBP levels after one-year medical weight management in s...

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Published in:PloS one 2018-11, Vol.13 (11), p.e0207882-e0207882
Main Authors: Nien, Hsiao-Ching, Sheu, Jin-Chuan, Chi, Yu-Chiao, Chen, Chi-Ling, Kao, Jia-Horng, Yang, Wei-Shiung
Format: Article
Language:English
Subjects:
Alcoholism
Atherosclerosis
BASIC (programming language)
Bioindicators
Biology and Life Sciences
Biomarkers
Body composition
Body mass
Body mass index
Body size
Body weight
Body weight loss
C-reactive protein
Clinical medicine
Data processing
Diabetes
Disease control
Disease prevention
Endotoxemia
Fatty liver
Fibrosis
Gastroenterology
Gastrointestinal surgery
Gene expression
Health care
Hospitals
Hypertension
Infections
Information management
Insulin resistance
Internal medicine
Leukocytes
Lipopolysaccharide-binding protein
Lipopolysaccharides
Liver
Liver diseases
Management
Medicine and Health Sciences
Metabolic disorders
Metabolic syndrome
Obesity
Overweight
Preventive medicine
Proteins
Regression analysis
Surgery
Ultrasonic imaging
Ultrasound
Viral infections
Weight control
Weight loss
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description Studies showed that the endotoxemia-related biomarker, lipopolysaccharide-binding protein (LBP), is associated with obesity and fatty liver. The level of LBP is reduced after surgical weight loss. This study aimed to verify the change of serum LBP levels after one-year medical weight management in subjects with obesity. A total of 62 subjects with obesity, 39 subjects with overweight, and 21 subjects with normal body mass index were enrolled for a one-year weight management program. Basic information, body composition analysis, clinical data, serum LBP level, and abdominal ultrasonography findings were collected. At baseline, the serum LBP levels of the obese and overweight subjects were significantly higher than that of the normal group (30.9±7.4 and 29.6±6.3 versus 23.1±5.6 μg/mL, respectively, p
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The level of LBP is reduced after surgical weight loss. This study aimed to verify the change of serum LBP levels after one-year medical weight management in subjects with obesity. A total of 62 subjects with obesity, 39 subjects with overweight, and 21 subjects with normal body mass index were enrolled for a one-year weight management program. Basic information, body composition analysis, clinical data, serum LBP level, and abdominal ultrasonography findings were collected. At baseline, the serum LBP levels of the obese and overweight subjects were significantly higher than that of the normal group (30.9±7.4 and 29.6±6.3 versus 23.1±5.6 μg/mL, respectively, p&lt;0.001). Serum LBP in subjects with obesity was significantly reduced to 26.5±7.1 μg/mL (p-value &lt; 0.001) after one year. In the multivariate analyses, LBP was associated with high sensitive C-reactive protein (hs-CRP) and non-alcoholic fatty liver disease (NAFLD) fibrosis score (NFS) before weight management in the obese group. Moreover, the change of LBP in response to weight management was significantly related to the changes of hs-CRP, leukocyte count and NFS by multivariate linear regression analysis also in the obese group. The serum level of the endotoxemia-related biomarker, LBP, decreases after one-year weight management in the obese subjects. 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In the multivariate analyses, LBP was associated with high sensitive C-reactive protein (hs-CRP) and non-alcoholic fatty liver disease (NAFLD) fibrosis score (NFS) before weight management in the obese group. Moreover, the change of LBP in response to weight management was significantly related to the changes of hs-CRP, leukocyte count and NFS by multivariate linear regression analysis also in the obese group. The serum level of the endotoxemia-related biomarker, LBP, decreases after one-year weight management in the obese subjects. In addition to serving as a metainflammatroy biomarker like hs-CRP, LBP may also be a potential biomarker as a non-invasive biomarker for the evaluation of liver fibrosis in NAFLD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30458048</pmid><doi>10.1371/journal.pone.0207882</doi><orcidid>https://orcid.org/0000-0001-5087-373X</orcidid><oa>free_for_read</oa></addata></record>
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subjects Alcoholism
Atherosclerosis
BASIC (programming language)
Bioindicators
Biology and Life Sciences
Biomarkers
Body composition
Body mass
Body mass index
Body size
Body weight
Body weight loss
C-reactive protein
Clinical medicine
Data processing
Diabetes
Disease control
Disease prevention
Endotoxemia
Fatty liver
Fibrosis
Gastroenterology
Gastrointestinal surgery
Gene expression
Health care
Hospitals
Hypertension
Infections
Information management
Insulin resistance
Internal medicine
Leukocytes
Lipopolysaccharide-binding protein
Lipopolysaccharides
Liver
Liver diseases
Management
Medicine and Health Sciences
Metabolic disorders
Metabolic syndrome
Obesity
Overweight
Preventive medicine
Proteins
Regression analysis
Surgery
Ultrasonic imaging
Ultrasound
Viral infections
Weight control
Weight loss
title One-year weight management lowers lipopolysaccharide-binding protein and its implication in metainflammation and liver fibrosis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T00%3A33%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=One-year%20weight%20management%20lowers%20lipopolysaccharide-binding%20protein%20and%20its%20implication%20in%20metainflammation%20and%20liver%20fibrosis&rft.jtitle=PloS%20one&rft.au=Nien,%20Hsiao-Ching&rft.date=2018-11-20&rft.volume=13&rft.issue=11&rft.spage=e0207882&rft.epage=e0207882&rft.pages=e0207882-e0207882&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0207882&rft_dat=%3Cproquest_plos_%3E2136225142%3C/proquest_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c526t-d0e076133acb37a2fb2d656bde8a12ca9420f7d1f7aa75924e0bdc7fdb557b383%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2136225142&rft_id=info:pmid/30458048&rfr_iscdi=true