Rapid and substantial increases in anticoagulant use and expenditure in Australia following the introduction of new types of oral anticoagulants

• Published in: PloS one 2018-12, Vol.13 (12), p.e0208824-e0208824
• Main Authors: Morgan, Alice, Joshy, Grace, Schaffer, Andrea, Laba, Tracey-Lea, Litchfield, Melisa, Pearson, Sallie, Banks, Emily
• Format: Article
• Language: English
• Subjects: Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Anticoagulants - administration & dosage; Anticoagulants - economics; Atrial fibrillation; Atrial Fibrillation - economics; Atrial Fibrillation - epidemiology; Atrial Fibrillation - prevention & control; Australia - epidemiology; Beneficiaries; Cardiac arrhythmia; Costs and Cost Analysis; Dispensing; Dosage and administration; Economic aspects; Embolisms; Epidemiology; Expenditures; Female; Fibrillation; Financing, Government; Forecasts and trends; Government agencies; Government programs; Health care; Humans; Internal medicine; Ischemia; Male; Medical economics; Medicare; Medicine; Medicine and Health Sciences; Mortality; People and Places; Pharmaceuticals; Population; Prevention; Public expenditures; Public finance; Pulmonary embolisms; Retirement benefits; Statistical analysis; Stroke; Thromboembolism; Thrombosis; Time Factors; Time series; Trends; Vitamin K; Vitamins; Warfarin
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0208824

To quantify changes in anticoagulant use in Australia since the introduction of Non-vitamin K antagonist anticoagulants (NOACs) and to estimate government expenditure. Interrupted-time-series analysis quantifying anticoagulant dispensing, before and after first Pharmaceutical Benefits Scheme (PBS) NOAC listing in August 2009 for venous thromboembolism prevention; and expanded listing for stroke prevention in non-valvular atrial fibrillation (AF) in August 2013, up to June 2016. Estimated government expenditure on PBS-listed anticoagulants. PBS dispensing in 10% random sample of Australians, restricted to continuous concessional beneficiaries dispensed oral anticoagulants from July 2005 to June 2016. Total PBS anticoagulant expenditure was calculated using Medicare Australia statistics. Monthly dispensing and initiation of oral anticoagulants (warfarin, rivaroxaban, dabigatran or apixaban). Annual PBS anticoagulant expenditure. An estimated 149,180 concessional beneficiaries were dispensed anticoagulants (100% warfarin) during July 2005. This increased to 292,550 during June 2016, of whom 47.0%, 27.1%, 18.7% and 7.2% were dispensed warfarin, rivaroxaban, apixaban and dabigatran, respectively. Of 16,500 initiated on anticoagulants in June 2016, 24.3%, 38.2%, 30.0% and 7.5% were initiated on warfarin, rivaroxaban, apixaban, and dabigatran, respectively. Compared to July 2005-July 2013, from August 2013-June 2016, dispensings for all anticoagulants increased by 2,303 dispensings/month (p