Differential recordings of local field potential: A genuine tool to quantify functional connectivity

Local field potential (LFP) recording is a very useful electrophysiological method to study brain processes. However, this method is criticized for recording low frequency activity in a large area of extracellular space potentially contaminated by distal activity. Here, we theoretically and experime...

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Bibliographic Details
Published in:PloS one 2018-12, Vol.13 (12), p.e0209001-e0209001
Main Authors: Meyer, Gabriel, Carponcy, Julien, Salin, Paul Antoine, Comte, Jean-Christophe
Format: Article
Language:English
Subjects:
Algorithms
Animals
Biology and Life Sciences
Brain
Brain - physiology
Brain mapping
Brain research
CA1 Region, Hippocampal - physiology
Cortex
Direct reduction
Electrodes
Electroencephalography
Electromyography
Electrophysiological recording
Electrophysiology
Engineering and Technology
Life Sciences
Male
Medicine and Health Sciences
Microscopy
Nerve impulses
Neural networks
Neurons and Cognition
Neurosciences
Noise propagation
Observations
Physical Sciences
Prefrontal Cortex - physiology
Rats
Recording
Research and Analysis Methods
Signal to noise ratio
Sleep
Testing
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Summary:Local field potential (LFP) recording is a very useful electrophysiological method to study brain processes. However, this method is criticized for recording low frequency activity in a large area of extracellular space potentially contaminated by distal activity. Here, we theoretically and experimentally compare ground-referenced (RR) with differential recordings (DR). We analyze electrical activity in the rat cortex with these two methods. Compared with RR, DR reveals the importance of local phasic oscillatory activities and their coherence between cortical areas. Finally, we show that DR provides a more faithful assessment of functional connectivity caused by an increase in the signal to noise ratio, and of the delay in the propagation of information between two cortical structures.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0209001