Progesterone effects on vaginal cytokines in women with a history of preterm birth

To determine the effect of intramuscular progesterone on the vaginal immune response of pregnant women with a history of prior preterm birth. A prospective, cohort study of women at 11-16 weeks gestation, ≥18 years of age, and carrying a singleton pregnancy was conducted from June 2016 to August 201...

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Bibliographic Details
Published in:PloS one 2018-12, Vol.13 (12), p.e0209346-e0209346
Main Authors: Garry, David J, Baker, David A, Persad, Malini D, Peresleni, Tatyana, Kocis, Christina, Demishev, Michael
Format: Article
Language:English
Subjects:
17 alpha-Hydroxyprogesterone Caproate - administration & dosage
Administration, Intravaginal
Adolescent
Adult
Age
Biology and Life Sciences
Birth weight
Body mass
Childbirth & labor
Chronic illnesses
Cytokines
Data processing
Demographics
Demography
Diabetes mellitus
Female
Gene Expression Regulation - drug effects
Gestation
Gestational Age
Gynecology
Humans
Hypertension
Immune response
Immune system
Immunity, Innate - drug effects
Immunofluorescence
Infant, Newborn
Inflammation
Interleukin 1
Interleukin 13
Interleukin 2
Interleukin-13 - genetics
Interleukin-1alpha - genetics
Interleukin-1beta - genetics
Interleukin-2 - genetics
Medicine
Medicine and Health Sciences
Obstetrics
Pregnancy
Premature birth
Premature Birth - drug therapy
Premature Birth - genetics
Premature Birth - pathology
Progesterone
Progesterone - administration & dosage
Progestins - metabolism
Prospective Studies
Proteins
Reproductive health
Statistical analysis
Statistical methods
Vagina
Vagina - drug effects
Vagina - metabolism
Vagina - pathology
Vaginitis
Weight
Womens health
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Summary:To determine the effect of intramuscular progesterone on the vaginal immune response of pregnant women with a history of prior preterm birth. A prospective, cohort study of women at 11-16 weeks gestation, ≥18 years of age, and carrying a singleton pregnancy was conducted from June 2016 to August 2017 after IRB approval. Women in the progesterone arm had a history of preterm birth and received weekly intramuscular 17-hydroxyprogesterone caproate. Controls comprised of women with healthy, uncomplicated pregnancies. Excluded were women with vaginitis, diabetes mellitus, hypertension, or other chronic diseases affecting the immune response. A vaginal wash was performed at enrollment, at 26-28 weeks, and at 35-36 weeks gestation. Samples underwent semi-quantitative detection of human inflammatory markers. Immunofluorescence pixel density data was analyzed and a P value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0209346