Baseline Troponin T level in stroke and its association with stress cardiomyopathy

Differential diagnosis of elevated high sensitive Troponin T (hsTnT) in acute ischemic stroke includes myocardial infarction (MI) and neurogenic stunned myocardium (NSM). The aim of this study was to identify factors associated with baseline hsTnT levels and MI or NSM in acute ischemic stroke. We st...

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Published in:PloS one 2018-12, Vol.13 (12), p.e0209764-e0209764
Main Authors: Liesirova, Kai, Abela, Eugenio, Pilgrim, Thomas, Bickel, Laura, Meinel, Thomas, Meisterernst, Julia, Rajeev, Verma, Sarikaya, Hakan, Heldner, Mirjam R, Dobrocky, Tomas, Siqueira, Erick, El-Koussy, Marwan, Fischer, Urs, Gralla, Jan, Arnold, Marcel, Mattle, Heinrich P, Hsieh, Kety, Jung, Simon
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Angiography
Biology and Life Sciences
Blood clots
Brain
Calcium-binding protein
Cardiology
Cardiomyopathy
Cerebral infarction
Creatinine
Diagnosis
Differential diagnosis
EKG
Electrocardiography
Female
Heart
Heart attacks
Humans
Ischemia
Lesions
Magnetic Resonance Imaging
Male
Medicine and Health Sciences
Mental depression
Middle Aged
Myocardial infarction
Myocardium
Neuroimaging
Neurology
Patients
Perfusion
Prospective Studies
Regression analysis
Research and Analysis Methods
Retrospective Studies
Singular value decomposition
Stroke
Stroke - blood
Stroke - diagnosis
Takotsubo Cardiomyopathy - blood
Takotsubo Cardiomyopathy - diagnosis
Troponin
Troponin T
Troponin T - blood
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Summary:Differential diagnosis of elevated high sensitive Troponin T (hsTnT) in acute ischemic stroke includes myocardial infarction (MI) and neurogenic stunned myocardium (NSM). The aim of this study was to identify factors associated with baseline hsTnT levels and MI or NSM in acute ischemic stroke. We studied 204 consecutive patients of the prospective acquired Bern Stroke Database with acute ischemic stroke diagnosed by brain MR. All patient histories and cardiac examinations were reviewed retrospectively. Volumetry of lesions on diffusion and perfusion weighted brain imaging (circular singular value decomposition, Tmax >6sec) was performed. Voxel based analysis was performed to identify brain areas associated with hsTnT elevation. Linear regression analysis was used to identify predictors of baseline hsTnT levels and myocardial infarction. Elevated hsTnT was observed in 58 of the 204 patients (28.4%). The mean age was 68.3 years in the normal hsTnT group and 69.7 years in the elevated hsTnT group. Creatinine (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0209764