Increased von Willebrand factor parameters in children with febrile seizures

Primary blood coagulation and wound sealing are orchestrated by von Willebrand factor (VWF), a large multimeric glycoprotein. Upon release of arginine vasopressin (AVP), VWF containing high molecular weight multimers is secreted. By measuring copeptin, the C-terminal part of the AVP prohormone, we r...

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Bibliographic Details
Published in:PloS one 2019-01, Vol.14 (1), p.e0210004-e0210004
Main Authors: Pechmann, Astrid, Wellmann, Sven, Stoecklin, Benjamin, Krüger, Marcus, Zieger, Barbara
Format: Article
Language:English
Subjects:
Argipressin
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Blood coagulation
Central nervous system
Child, Preschool
Children
Coagulation
Collagen
Convulsions & seizures
Cross-Sectional Studies
Emergency medical services
Epilepsy
Febrile seizures
Female
Fever
Fever - blood
Fever - diagnosis
Glycopeptides - blood
Glycoproteins
Health aspects
Hematology
Hospitals
Humans
Infant
Infections
Laboratories
Male
Medicine
Medicine and Health Sciences
Molecular weight
Neurophysins - blood
Parameters
Pediatrics
Physical Sciences
Plasma levels
Prospective Studies
Protein Precursors - blood
Regression analysis
Research and Analysis Methods
Secretion
Seizing
Seizures
Seizures, Febrile - blood
Seizures, Febrile - diagnosis
Studies
Vasopressin
Vasopressins - blood
von Willebrand Diseases - blood
von Willebrand Diseases - diagnosis
Von Willebrand factor
von Willebrand Factor - metabolism
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Summary:Primary blood coagulation and wound sealing are orchestrated by von Willebrand factor (VWF), a large multimeric glycoprotein. Upon release of arginine vasopressin (AVP), VWF containing high molecular weight multimers is secreted. By measuring copeptin, the C-terminal part of the AVP prohormone, we recently found strongly increased AVP levels in children with febrile seizures (FS) as compared to children with fever but without seizures. It is unknown if increased AVP levels in FS are of any biological function. Therefore, our a priori hypothesis was that children with FS have increased VWF parameters in parallel with higher AVP levels. We conducted a prospective, cross-sectional study of children aged between 6 months and 5 years. Children that presented at our emergency department with fever or a recent FS (within four hours) were evaluated to be included to the study. We measured serum copeptin and VWF parameters, including analyses of VWF:Antigen (WVF:Ag), VWF:collagen binding activity (VWF:CB) and VWF multimers in children with FS, febrile infections without seizures and additionally, in a non-febrile control group. We included 54 children in our study, 30 with FS, 10 in the febrile control group, and 14 in the non-febrile control group. Serum copeptin levels were significantly higher in children with FS (median [IQR] 24.73 pmol/l [13.65-68.65]) compared to the febrile control group (5.66 pmol/l [4.15-8.07], p = 0.002) and the non-febrile control group (4.78 pmol/l [3.33-5.3], p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0210004