Interactive effects of OXTR and GAD1 on envy-associated behaviors and neural responses

Inequity aversion (negative feelings induced by outcome differences between the self and other) plays a key role in human social behaviors. The neurotransmitters oxytocin and GABA have been implicated in neural responses to inequity. However, it remains poorly understood not only how individual gene...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2019-01, Vol.14 (1), p.e0210493-e0210493
Main Authors: Tanaka, Toshiko, Nishimura, Fumichika, Kakiuchi, Chihiro, Kasai, Kiyoto, Kimura, Minoru, Haruno, Masahiko
Format: Article
Language:English
Subjects:
Age
Algorithms
Altruism
Analysis
Autism
Aversion
Behavior
Biology and Life Sciences
Brain
Brain - diagnostic imaging
Brain - metabolism
Brain - physiology
Consent
Decision Making
Epistasis, Genetic
Experiments
Female
GABA
Games
Gene Frequency
Genes
Genetic effects
Genetic factors
Genotype
Genotypes
Glutamate decarboxylase
Glutamate Decarboxylase - genetics
Human behavior
Humans
Influence
Jealousy
Magnetic Resonance Imaging - methods
Male
Medicine and Health Sciences
Neural networks
Neural receptors
Neurotransmitters
NMR
Nuclear magnetic resonance
Oxytocin
Physical Sciences
Polymorphism
Polymorphism, Single Nucleotide
Psychomotor Performance - physiology
Receptors, Oxytocin - genetics
Research and Analysis Methods
Single nucleotide polymorphisms
Social Behavior
Social Sciences
Studies
Substrates
Young Adult
γ-Aminobutyric acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Inequity aversion (negative feelings induced by outcome differences between the self and other) plays a key role in human social behaviors. The neurotransmitters oxytocin and GABA have been implicated in neural responses to inequity. However, it remains poorly understood not only how individual genetic factors related to oxytocin and GABA affect the neural mechanisms behind inequity aversion, but also how these genes interact. To address these issues, we examined relationships between genotypes, behavioral decisions and brain activities during the ultimatum game. We identified interactive effects between the polymorphisms of the oxytocin receptor gene (OXTR) and glutamate decarboxylase 1 gene for GABA synthesis (GAD1) on envy aversion (i.e., disadvantageous inequity aversion) and on envy-induced activity in the dorsal ACC (dACC). Thus, our integrated approach suggested interactive genetic effects between OXTR and GAD1 on envy aversion and the underlying neural substrates.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0210493