Trends in the risk of myocardial infarction among HIV-1-infected individuals relative to the general population in France: Impact of gender and immune status

We examined trends in the MI incidence and age at MI diagnosis among adults living with HIV-1 between 2000 and 2009, by comparison with the French MI registries, by gender. Age standardized incidence rates and standardized incidence-ratios (SIRs) were estimated for individuals included in the French...

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Bibliographic Details
Published in:PloS one 2019-01, Vol.14 (1), p.e0210253-e0210253
Main Authors: Baldé, Aliou, Lang, Sylvie, Wagner, Aline, Ferrières, Jean, Montaye, Michèle, Tattevin, Pierre, Cotte, Laurent, Aslangul, Elisabeth, Bidégain, Frédéric, Chéret, Antoine, Mary-Krause, Murielle, Meynard, Jean-Luc, Molina, Jean-Michel, Partisani, Marialuisa, Roger, Pierre-Marie, Boccara, Franck, Costagliola, Dominique
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
Adults
Age
Age Factors
AIDS
Anti-HIV Agents - therapeutic use
Biology and Life Sciences
Cardiology and cardiovascular system
Cardiovascular disease
CD4 antigen
Databases, Factual
Diagnosis
Female
France - epidemiology
Health aspects
Health risk assessment
Health risks
Heart attack
Heart attacks
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - virology
HIV patients
HIV-1
Human health and pathology
Human immunodeficiency virus
Humans
Immune status
Incidence
Infectious diseases
Life Sciences
Male
Medical diagnosis
Medicine and Health Sciences
Men
Middle Aged
Mood
Myocardial infarction
Myocardial Infarction - complications
Myocardial Infarction - epidemiology
People and places
Risk assessment
Risk Factors
Santé publique et épidémiologie
Sex Factors
Sexually transmitted diseases
Social Sciences
STD
Trends
Viral Load
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Items that cite this one
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Summary:We examined trends in the MI incidence and age at MI diagnosis among adults living with HIV-1 between 2000 and 2009, by comparison with the French MI registries, by gender. Age standardized incidence rates and standardized incidence-ratios (SIRs) were estimated for individuals included in the French hospital database on HIV (n = 71 204, MI = 663) during three periods: 2000-2002, 2003-2005 and 2006-2009. Median ages at MI diagnosis were compared using the Brown-Mood test. Over the study periods, the absolute rate difference and relative risks were higher in women than in men in 2000-2002 and 2006-2009, with respective SIRs 1.99 (1.39-2.75) and 1.12 (0.99-1.27) in 2006-2009. The trends were different for men and women with a decreasing trend in SIRs in men and no change in women. In both sexes, among individuals with CD4 ≥500/μL and controlled viral-load on cART, the risk was no longer elevated. Age at MI diagnosis was significantly younger than in the general population, especially among women (-6.2 years, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0210253