Resistin-Can it be a new early marker for prognosis in patients who survive after a cardiac arrest? A pilot study

The aim of our study was to evaluate the potential role of resistin in estimating the 30 days prognosis in patients with hypoxic-ischemic organ injury who survived after a cardiac arrest (CA). The study included 40 patients resuscitated after a non-traumatic out-of-hospital CA admitted in Emergency...

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Bibliographic Details
Published in:PloS one 2019-01, Vol.14 (1), p.e0210666-e0210666
Main Authors: Tat, Raluca Mihaela, Golea, Adela, Vesa, Ştefan Cristian, Ionescu, Daniela
Format: Article
Language:English
Subjects:
Adipocytes
Adolescent
Adult
Aged
Aged, 80 and over
Biological markers
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Cardiac arrest
Cardiopulmonary resuscitation
Cell adhesion & migration
Councils
CPR
Diagnosis
Electrical impedance
Emergency medical services
Female
Heart
Heart Arrest - blood
Heart Arrest - mortality
Heart Arrest - pathology
Hospitals
Humans
Hypoxia
Injuries
Intensive care
Ischemia
Lactic acid
Longitudinal Studies
Male
Medical prognosis
Medicine
Medicine and Health Sciences
Metabolism
Middle Aged
Mortality
Patients
Pharmacy
Phosphopyruvate hydratase
Pilot Projects
Plasma levels
Prognosis
Prospective Studies
Proteins
Resistin - blood
Resuscitation
S100b protein
Sensitivity
Sepsis
Serum levels
Young Adult
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Summary:The aim of our study was to evaluate the potential role of resistin in estimating the 30 days prognosis in patients with hypoxic-ischemic organ injury who survived after a cardiac arrest (CA). The study included 40 patients resuscitated after a non-traumatic out-of-hospital CA admitted in Emergency Department (ED). All patients were followed for 30 days after CA or until death. Clinical data on admission were recorded. Blood samples were collected on admission in ED (0-time interval), and at 6, 12, 24, 48- and 72-hours following resuscitation. Serum concentrations of resistin, S100B and neuron specific enolase (NSE) were measured. Several predictive scores for the mortality at 30 days were created with logistic regressions. At each time interval, median serum levels of resistin and S100 B were significantly higher in non-survivors compared to survivors. For NSE, plasma levels were significantly lower in survivors as compared to non-survivors at 48 and 72 hours, respectively. Accurate predictive scores for 30-days mortality were the ones which included the values of resistin and S100B measured at 12 hours after admittance [AUC 0.938 (0.813-0.989), sensitivity 85.71% (67.3%- 96%), specificity 91.67% (61.5%'99.8%), p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0210666