Time course of tolerance to the performance benefits of caffeine

The ergogenic effect of acute caffeine ingestion has been widely investigated; however, scientific information regarding tolerance to the performance benefits of caffeine, when ingested on a day-to-day basis, is scarce. The aim of this investigation was to determine the time course of tolerance to t...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2019-01, Vol.14 (1), p.e0210275-e0210275
Main Authors: Lara, Beatriz, Ruiz-Moreno, Carlos, Salinero, Juan José, Del Coso, Juan
Format: Article
Language:English
Subjects:
Adenosine
Adult
Analysis
Animal cognition
Binding sites
Biology and Life Sciences
Caffeine
Caffeine - pharmacology
Central Nervous System Stimulants - pharmacology
Consumption
Cross-Over Studies
Crossovers
Cycles
Dosage and administration
Double-Blind Method
Drug Tolerance
Energy drinks
Exercise
Exercise physiology
Exercise tests
Fatigue
Fatigue - chemically induced
Fatigue tests
Female
Gene expression
Health aspects
Humans
Ingestion
Laboratories
Male
Medicine and Health Sciences
Neurosciences
Oxygen Consumption - drug effects
Performance-Enhancing Substances - pharmacology
Physical Sciences
Physiological aspects
Psychopharmacology
Research and Analysis Methods
Toleration
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The ergogenic effect of acute caffeine ingestion has been widely investigated; however, scientific information regarding tolerance to the performance benefits of caffeine, when ingested on a day-to-day basis, is scarce. The aim of this investigation was to determine the time course of tolerance to the ergogenic effects of a moderate dose of caffeine. Eleven healthy active participants took part in a cross-over, double-blind, placebo-controlled experiment. In one treatment, they ingested 3 mg/kg/day of caffeine for 20 consecutive days while in another they ingested a placebo for 20 days. Each substance was administered daily in an opaque unidentifiable capsule, and the experimental trials started 45 min after capsule ingestion. Two days before, and three times per week during each 20-day treatment, aerobic peak power was measured with an incremental test to volitional fatigue (25 W/min) and aerobic peak power was measured with an adapted version of the Wingate test (15 s). In comparison to the placebo, the ingestion of caffeine increased peak cycling power in the incremental exercise test by ~4.0 ±1.3% for the first 15 days (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0210275