Fc gamma RIIb expression levels in human liver sinusoidal endothelial cells during progression of non-alcoholic fatty liver disease

• Published in: PloS one 2019-01, Vol.14 (1), p.e0211543-e0211543
• Main Authors: Ishikawa, Tomoko, Yokoyama, Hiroshi, Matsuura, Tomokazu, Fujiwara, Yoko
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antigen-antibody complexes; Biology and Life Sciences; Biomarkers - metabolism; Biopsy; Blood lipids; Capillaries - metabolism; Capillaries - pathology; Cholesterol; Collagen; Correlation; Development and progression; Disease Progression; Endocytosis; Endothelial cells; Endothelium; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; Fatty liver; Fc receptors; Female; Fibrosis; Gene expression; Genetic aspects; Hepatitis; Hepatocytes; Hepatology; Homeostasis; Humans; Hyaluronic acid; Immune clearance; Immunohistochemistry; Inflammation; Laboratories; Lipid metabolism; Lipids; Liver; Liver cancer; Liver diseases; Male; Medical schools; Medicine; Medicine and Health Sciences; Metabolism; Middle Aged; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; Physiological aspects; Prognosis; Receptors; Receptors, IgG - metabolism; Rodents; Scavenger receptors; Serum levels; Triglycerides; Waste materials
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0211543

Liver sinusoidal endothelial cells (LSECs) play a pivotal role in hepatic function and homeostasis. LSEC dysfunction has been recognized to be closely involved in various liver diseases, including non-alcoholic steatohepatitis (NASH), but not much is known about the fate of the scavenger receptors in LSECs during NASH. Fc gamma receptor IIb (FcγRIIb), known as a scavenger receptor, contributes to receptor-mediated endocytosis and immune complexes clearance. In this study, to elucidate the fate of FcγRIIb in the progression of non-alcoholic fatty liver disease (NAFLD), we examined FcγRIIb levels in NAFLD biopsy specimens by immunohistochemistry, and investigated their correlation with the exacerbation of biological indexes and clinicopathological scores of NASH. The FcγRIIb expression levels indicated significant negative correlations with serum levels of blood lipids (triglyceride, total cholesterol, high-density lipoprotein-cholesterol), type 4 collagen and hyaluronic acid, which are involved in hepatic lipid metabolism disorder, fibrosis, and inflammation, respectively. However, there was no significant difference of FcγRIIb expression levels among the pathological grades of NAFLD. During NAFLD progression, inflammation and fibrosis may influence the expression of FcγRIIb and their scavenger functions to maintain hepatic homeostasis.