Prevalence of malaria and hepatitis B among pregnant women in Northern Ghana: Comparing RDTs with PCR

High prevalence of malaria and hepatitis B has been reported among pregnant women in Ghana. In endemic areas, the diagnoses of malaria and hepatitis B among pregnant women on antenatal visits are done using histidine-rich protein 2 (HRP2) and hepatitis B surface antigen (HBsAg) rapid diagnostic test...

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Bibliographic Details
Published in:PloS one 2019-02, Vol.14 (2), p.e0210365
Main Authors: Anabire, Nsoh Godwin, Aryee, Paul Armah, Abdul-Karim, Abass, Abdulai, Issah Bakari, Quaye, Osbourne, Awandare, Gordon Akanzuwine, Helegbe, Gideon Kofi
Format: Article
Language:English
Subjects:
Adult
Analysis
Antigens
Antigens, Protozoan - blood
Biochemistry
Biology and Life Sciences
Cross-Sectional Studies
Diagnostic systems
Economics
Female
Food and nutrition
Ghana - epidemiology
Health aspects
Health risks
Health sciences
Hepatitis
Hepatitis B
Hepatitis B - blood
Hepatitis B - epidemiology
Hepatitis B surface antigen
Hepatitis B Surface Antigens - blood
Hepatitis B virus
Histidine
Humans
Infections
Infectious diseases
Laboratories
Malaria
Malaria, Falciparum - blood
Malaria, Falciparum - epidemiology
Medical tests
Medicine
Medicine and Health Sciences
Molecular biology
Obstetrics
Pathogens
Plasmodium falciparum
Polymerase chain reaction
Pregnancy
Pregnancy Complications, Infectious - blood
Pregnancy Complications, Infectious - epidemiology
Pregnant women
Prenatal care
Proteins
Protozoan Proteins - blood
Public health
Regression analysis
Research and Analysis Methods
Social class
Socioeconomic factors
Socioeconomics
Statistical analysis
Statistical tests
Studies
Vector-borne diseases
Viruses
Womens health
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Summary:High prevalence of malaria and hepatitis B has been reported among pregnant women in Ghana. In endemic areas, the diagnoses of malaria and hepatitis B among pregnant women on antenatal visits are done using histidine-rich protein 2 (HRP2) and hepatitis B surface antigen (HBsAg) rapid diagnostic tests (RDTs), respectively, which are, however, reported to give some false positive results. Also, socio-economic determinants have been drawn from these RDTs results which may have questionable implications. Thus, this study was aimed at evaluating the prevalence of malaria and hepatitis B by comparing RDTs with polymerase chain reaction (PCR) outcomes, and relating the PCR prevalence with socio-economic status among pregnant women in Northern Ghana. We screened 2071 pregnant women on their first antenatal visit for Plasmodium falciparum and hepatitis B virus (HBV) using HRP2 and HBsAg RDTs, and confirming the infections with PCR. Socio-economic and obstetric information were collected using a pre-tested questionnaire, and associations with the infections were determined using Pearson's chi-square and multinomial logistic regression analyses at a significance level of p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0210365