Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model

As Alzheimer's disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellul...

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Bibliographic Details
Published in:PloS one 2019-02, Vol.14 (2), p.e0212663
Main Authors: Caillaud, Martial, Guillard, Jérôme, Richard, Damien, Milin, Serge, Chassaing, Damien, Paccalin, Marc, Page, Guylène, Rioux Bilan, Agnès
Format: Article
Language:English
Subjects:
Alzheimer Disease - drug therapy
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid
Animal cognition
Animals
Astrocytes
Astrocytes - drug effects
Astrocytes - pathology
Benzofurans - pharmacokinetics
Benzofurans - therapeutic use
Binding sites
Biology and Life Sciences
Blood-brain barrier
Brain
Brain research
Disaggregation
Disease Models, Animal
Engineering and Technology
Female
Fluorides
Human health and pathology
Inflammation
Inflammation - drug therapy
Inflammation - pathology
Inflammatory response
Laboratories
Life Sciences
Male
Medicine and Health Sciences
Mice
Mice, Transgenic
Microglia
Microglia - drug effects
Microglia - pathology
Neurobiology
Neurosciences
Peptides
Plaque, Amyloid - drug therapy
Plaque, Amyloid - pathology
Polyethylene glycol
Polyphenols
R&D
Research & development
Research and Analysis Methods
Rodents
Stilbenes - pharmacokinetics
Stilbenes - therapeutic use
Transgenic animals
Transgenic mice
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Summary:As Alzheimer's disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. We report that trans ε-viniferin could go through the blood brain barrier, reduces size and density of amyloid deposits and decreases reactivity of astrocytes and microglia, after a weekly intraperitoneal injection at 10 mg/kg from 3 to 6 months of age.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0212663