Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity

Abdominal or visceral obesity is a well-known risk factor for metabolic diseases. However, whether abdominal obesity significantly affects plasma lipid profile during the development of type 2 diabetes has not been fully elucidated. We investigated the differences in plasma lipid concentrations in 6...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2019-03, Vol.14 (3), p.e0213285
Main Authors: Im, Seung-Soon, Park, Hyeon Young, Shon, Jong Cheol, Chung, In-Sung, Cho, Ho Chan, Liu, Kwang-Hyeon, Song, Dae-Kyu
Format: Article
Language:English
Subjects:
Abdomen
Adipose tissue
Adult
Asian Americans
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Blood plasma
Blood pressure
Body mass index
Ceramide
Chromatography
Development and progression
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetics
Endocrinology
Glucose
Health aspects
Health risks
Hemoglobin
Hip
Humans
Hypertension
Incidence
Insulin resistance
Lecithin
Lipids
Lipids - blood
Liquid chromatography
Liver
Male
Mass spectrometry
Mass spectroscopy
Medical research
Medicine
Medicine and Health Sciences
Metabolic syndrome
Metabolism
Metabolites
Middle Aged
Obesity
Obesity, Abdominal - blood
Obesity, Abdominal - physiopathology
Pharmaceutical sciences
Pharmacy
Phosphatidylcholine
Phospholipids
Physiology
Plant lipids
Prediabetic state
Prediabetic State - blood
Prediabetic State - epidemiology
Republic of Korea - epidemiology
Risk analysis
Risk Factors
Spectroscopy
Sphingolipids
Sphingomyelin
Sphingomyelins - blood
Type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c692t-76ca79aa1f7d6b6abbe7521b171792163e87b26aa35a7f6b804fd7c3b0d300b3
cites cdi_FETCH-LOGICAL-c692t-76ca79aa1f7d6b6abbe7521b171792163e87b26aa35a7f6b804fd7c3b0d300b3
container_end_page
container_issue 3
container_start_page e0213285
container_title PloS one
container_volume 14
creator Im, Seung-Soon
Park, Hyeon Young
Shon, Jong Cheol
Chung, In-Sung
Cho, Ho Chan
Liu, Kwang-Hyeon
Song, Dae-Kyu
description Abdominal or visceral obesity is a well-known risk factor for metabolic diseases. However, whether abdominal obesity significantly affects plasma lipid profile during the development of type 2 diabetes has not been fully elucidated. We investigated the differences in plasma lipid concentrations in 63 participants categorized into six groups (middle-aged Korean men); Normal, Pre-diabetes (pre-DM), and Diabetes mellitus (DM) with or without abdominal obesity (AO or lean). The lipidomic profiles were determined by using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Sphingomyelin (SM) levels in plasma were significantly higher in the pre-DM with AO than in pre-DM with lean (p = 0.021). SM concentrations correlated positively with waist-to-hip ratio (WHR) (r = 0.256, p = 0.044), cholesteryl ester (CE) (r = 0.483, p < 0.0001), ceramide (r = 0.489, p < 0.0001) and plasmanyl phosphatidylcholine (PC) (r = 0.446, p < 0.0001). The present study found that pre-diabetic patients with AO were characterized by increased plasma concentrations of SM. Plasma SM levels in individuals with AO may be an early prognostic biomarker to better predict the progression toward type 2 diabetes and metabolic syndrome.
doi_str_mv 10.1371/journal.pone.0213285
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2188347244</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A577131543</galeid><doaj_id>oai_doaj_org_article_47081424d9714d71b7218a8036081b19</doaj_id><sourcerecordid>A577131543</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-76ca79aa1f7d6b6abbe7521b171792163e87b26aa35a7f6b804fd7c3b0d300b3</originalsourceid><addsrcrecordid>eNqNkl-L1DAUxYMo7jr6DUQLwoIPHfOvSedFWJZVBxd20cXXcNOmnQxtMiatOt_erNNdpqAgeUi4-d2Tm8NB6CXBS8Ikebf1Y3DQLXfemSWmhNGyeIROyYrRXFDMHh-dT9CzGLcYF6wU4ik6YbhkhSzYKbq56SD2kMXdxrrW93vTWRcz66pgIJp0yHbB5LUFbQZbZZ99qrusNy77aYdNBrr2vU1zZF6baIf9c_SkgS6aF9O-QLcfLm8vPuVX1x_XF-dXeSVWdMilqECuAEgja6EFaG1kQYkmksgVJYKZUmoqAFgBshG6xLypZcU0rhnGmi3Q64PsrvNRTV5ERUlZMi4p54lYH4jaw1btgu0h7JUHq_4UfGgVhPSlzigucUk45fVKEl5LomXSgRIzkeo6ubhA76fXRt2bujJuCNDNROc3zm5U638owTFmaaQFejMJBP99NHH4x8gT1UKayrrGJ7Gqt7FS54WUhJGCs0Qt_0KlVZveVikNjU31WcPbWUNiBvNraGGMUa2_fvl_9vrbnD07YjcGumETfTcO1rs4B_kBrIKPMZjmwTmC1V2Y791Qd2FWU5hT26tj1x-a7tPLfgOhAu32</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2188347244</pqid></control><display><type>article</type><title>Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Im, Seung-Soon ; Park, Hyeon Young ; Shon, Jong Cheol ; Chung, In-Sung ; Cho, Ho Chan ; Liu, Kwang-Hyeon ; Song, Dae-Kyu</creator><contributor>Kim, Kyoung Heon</contributor><creatorcontrib>Im, Seung-Soon ; Park, Hyeon Young ; Shon, Jong Cheol ; Chung, In-Sung ; Cho, Ho Chan ; Liu, Kwang-Hyeon ; Song, Dae-Kyu ; Kim, Kyoung Heon</creatorcontrib><description>Abdominal or visceral obesity is a well-known risk factor for metabolic diseases. However, whether abdominal obesity significantly affects plasma lipid profile during the development of type 2 diabetes has not been fully elucidated. We investigated the differences in plasma lipid concentrations in 63 participants categorized into six groups (middle-aged Korean men); Normal, Pre-diabetes (pre-DM), and Diabetes mellitus (DM) with or without abdominal obesity (AO or lean). The lipidomic profiles were determined by using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Sphingomyelin (SM) levels in plasma were significantly higher in the pre-DM with AO than in pre-DM with lean (p = 0.021). SM concentrations correlated positively with waist-to-hip ratio (WHR) (r = 0.256, p = 0.044), cholesteryl ester (CE) (r = 0.483, p &lt; 0.0001), ceramide (r = 0.489, p &lt; 0.0001) and plasmanyl phosphatidylcholine (PC) (r = 0.446, p &lt; 0.0001). The present study found that pre-diabetic patients with AO were characterized by increased plasma concentrations of SM. Plasma SM levels in individuals with AO may be an early prognostic biomarker to better predict the progression toward type 2 diabetes and metabolic syndrome.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0213285</identifier><identifier>PMID: 30835753</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Adipose tissue ; Adult ; Asian Americans ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Blood plasma ; Blood pressure ; Body mass index ; Ceramide ; Chromatography ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetics ; Endocrinology ; Glucose ; Health aspects ; Health risks ; Hemoglobin ; Hip ; Humans ; Hypertension ; Incidence ; Insulin resistance ; Lecithin ; Lipids ; Lipids - blood ; Liquid chromatography ; Liver ; Male ; Mass spectrometry ; Mass spectroscopy ; Medical research ; Medicine ; Medicine and Health Sciences ; Metabolic syndrome ; Metabolism ; Metabolites ; Middle Aged ; Obesity ; Obesity, Abdominal - blood ; Obesity, Abdominal - physiopathology ; Pharmaceutical sciences ; Pharmacy ; Phosphatidylcholine ; Phospholipids ; Physiology ; Plant lipids ; Prediabetic state ; Prediabetic State - blood ; Prediabetic State - epidemiology ; Republic of Korea - epidemiology ; Risk analysis ; Risk Factors ; Spectroscopy ; Sphingolipids ; Sphingomyelin ; Sphingomyelins - blood ; Type 2 diabetes</subject><ispartof>PloS one, 2019-03, Vol.14 (3), p.e0213285</ispartof><rights>COPYRIGHT 2019 Public Library of Science</rights><rights>2019 Im et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 Im et al 2019 Im et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-76ca79aa1f7d6b6abbe7521b171792163e87b26aa35a7f6b804fd7c3b0d300b3</citedby><cites>FETCH-LOGICAL-c692t-76ca79aa1f7d6b6abbe7521b171792163e87b26aa35a7f6b804fd7c3b0d300b3</cites><orcidid>0000-0002-3285-5594</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2188347244/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2188347244?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30835753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kim, Kyoung Heon</contributor><creatorcontrib>Im, Seung-Soon</creatorcontrib><creatorcontrib>Park, Hyeon Young</creatorcontrib><creatorcontrib>Shon, Jong Cheol</creatorcontrib><creatorcontrib>Chung, In-Sung</creatorcontrib><creatorcontrib>Cho, Ho Chan</creatorcontrib><creatorcontrib>Liu, Kwang-Hyeon</creatorcontrib><creatorcontrib>Song, Dae-Kyu</creatorcontrib><title>Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Abdominal or visceral obesity is a well-known risk factor for metabolic diseases. However, whether abdominal obesity significantly affects plasma lipid profile during the development of type 2 diabetes has not been fully elucidated. We investigated the differences in plasma lipid concentrations in 63 participants categorized into six groups (middle-aged Korean men); Normal, Pre-diabetes (pre-DM), and Diabetes mellitus (DM) with or without abdominal obesity (AO or lean). The lipidomic profiles were determined by using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Sphingomyelin (SM) levels in plasma were significantly higher in the pre-DM with AO than in pre-DM with lean (p = 0.021). SM concentrations correlated positively with waist-to-hip ratio (WHR) (r = 0.256, p = 0.044), cholesteryl ester (CE) (r = 0.483, p &lt; 0.0001), ceramide (r = 0.489, p &lt; 0.0001) and plasmanyl phosphatidylcholine (PC) (r = 0.446, p &lt; 0.0001). The present study found that pre-diabetic patients with AO were characterized by increased plasma concentrations of SM. Plasma SM levels in individuals with AO may be an early prognostic biomarker to better predict the progression toward type 2 diabetes and metabolic syndrome.</description><subject>Abdomen</subject><subject>Adipose tissue</subject><subject>Adult</subject><subject>Asian Americans</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood plasma</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Ceramide</subject><subject>Chromatography</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetics</subject><subject>Endocrinology</subject><subject>Glucose</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Hemoglobin</subject><subject>Hip</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Insulin resistance</subject><subject>Lecithin</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Liquid chromatography</subject><subject>Liver</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic syndrome</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Abdominal - blood</subject><subject>Obesity, Abdominal - physiopathology</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacy</subject><subject>Phosphatidylcholine</subject><subject>Phospholipids</subject><subject>Physiology</subject><subject>Plant lipids</subject><subject>Prediabetic state</subject><subject>Prediabetic State - blood</subject><subject>Prediabetic State - epidemiology</subject><subject>Republic of Korea - epidemiology</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Spectroscopy</subject><subject>Sphingolipids</subject><subject>Sphingomyelin</subject><subject>Sphingomyelins - blood</subject><subject>Type 2 diabetes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl-L1DAUxYMo7jr6DUQLwoIPHfOvSedFWJZVBxd20cXXcNOmnQxtMiatOt_erNNdpqAgeUi4-d2Tm8NB6CXBS8Ikebf1Y3DQLXfemSWmhNGyeIROyYrRXFDMHh-dT9CzGLcYF6wU4ik6YbhkhSzYKbq56SD2kMXdxrrW93vTWRcz66pgIJp0yHbB5LUFbQZbZZ99qrusNy77aYdNBrr2vU1zZF6baIf9c_SkgS6aF9O-QLcfLm8vPuVX1x_XF-dXeSVWdMilqECuAEgja6EFaG1kQYkmksgVJYKZUmoqAFgBshG6xLypZcU0rhnGmi3Q64PsrvNRTV5ERUlZMi4p54lYH4jaw1btgu0h7JUHq_4UfGgVhPSlzigucUk45fVKEl5LomXSgRIzkeo6ubhA76fXRt2bujJuCNDNROc3zm5U638owTFmaaQFejMJBP99NHH4x8gT1UKayrrGJ7Gqt7FS54WUhJGCs0Qt_0KlVZveVikNjU31WcPbWUNiBvNraGGMUa2_fvl_9vrbnD07YjcGumETfTcO1rs4B_kBrIKPMZjmwTmC1V2Y791Qd2FWU5hT26tj1x-a7tPLfgOhAu32</recordid><startdate>20190305</startdate><enddate>20190305</enddate><creator>Im, Seung-Soon</creator><creator>Park, Hyeon Young</creator><creator>Shon, Jong Cheol</creator><creator>Chung, In-Sung</creator><creator>Cho, Ho Chan</creator><creator>Liu, Kwang-Hyeon</creator><creator>Song, Dae-Kyu</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3285-5594</orcidid></search><sort><creationdate>20190305</creationdate><title>Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity</title><author>Im, Seung-Soon ; Park, Hyeon Young ; Shon, Jong Cheol ; Chung, In-Sung ; Cho, Ho Chan ; Liu, Kwang-Hyeon ; Song, Dae-Kyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-76ca79aa1f7d6b6abbe7521b171792163e87b26aa35a7f6b804fd7c3b0d300b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdomen</topic><topic>Adipose tissue</topic><topic>Adult</topic><topic>Asian Americans</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood plasma</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Ceramide</topic><topic>Chromatography</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetics</topic><topic>Endocrinology</topic><topic>Glucose</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Hemoglobin</topic><topic>Hip</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Incidence</topic><topic>Insulin resistance</topic><topic>Lecithin</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Liquid chromatography</topic><topic>Liver</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Metabolic syndrome</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Abdominal - blood</topic><topic>Obesity, Abdominal - physiopathology</topic><topic>Pharmaceutical sciences</topic><topic>Pharmacy</topic><topic>Phosphatidylcholine</topic><topic>Phospholipids</topic><topic>Physiology</topic><topic>Plant lipids</topic><topic>Prediabetic state</topic><topic>Prediabetic State - blood</topic><topic>Prediabetic State - epidemiology</topic><topic>Republic of Korea - epidemiology</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Spectroscopy</topic><topic>Sphingolipids</topic><topic>Sphingomyelin</topic><topic>Sphingomyelins - blood</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Im, Seung-Soon</creatorcontrib><creatorcontrib>Park, Hyeon Young</creatorcontrib><creatorcontrib>Shon, Jong Cheol</creatorcontrib><creatorcontrib>Chung, In-Sung</creatorcontrib><creatorcontrib>Cho, Ho Chan</creatorcontrib><creatorcontrib>Liu, Kwang-Hyeon</creatorcontrib><creatorcontrib>Song, Dae-Kyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database (ProQuest)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Im, Seung-Soon</au><au>Park, Hyeon Young</au><au>Shon, Jong Cheol</au><au>Chung, In-Sung</au><au>Cho, Ho Chan</au><au>Liu, Kwang-Hyeon</au><au>Song, Dae-Kyu</au><au>Kim, Kyoung Heon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2019-03-05</date><risdate>2019</risdate><volume>14</volume><issue>3</issue><spage>e0213285</spage><pages>e0213285-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Abdominal or visceral obesity is a well-known risk factor for metabolic diseases. However, whether abdominal obesity significantly affects plasma lipid profile during the development of type 2 diabetes has not been fully elucidated. We investigated the differences in plasma lipid concentrations in 63 participants categorized into six groups (middle-aged Korean men); Normal, Pre-diabetes (pre-DM), and Diabetes mellitus (DM) with or without abdominal obesity (AO or lean). The lipidomic profiles were determined by using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Sphingomyelin (SM) levels in plasma were significantly higher in the pre-DM with AO than in pre-DM with lean (p = 0.021). SM concentrations correlated positively with waist-to-hip ratio (WHR) (r = 0.256, p = 0.044), cholesteryl ester (CE) (r = 0.483, p &lt; 0.0001), ceramide (r = 0.489, p &lt; 0.0001) and plasmanyl phosphatidylcholine (PC) (r = 0.446, p &lt; 0.0001). The present study found that pre-diabetic patients with AO were characterized by increased plasma concentrations of SM. Plasma SM levels in individuals with AO may be an early prognostic biomarker to better predict the progression toward type 2 diabetes and metabolic syndrome.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>30835753</pmid><doi>10.1371/journal.pone.0213285</doi><tpages>e0213285</tpages><orcidid>https://orcid.org/0000-0002-3285-5594</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2019-03, Vol.14 (3), p.e0213285
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2188347244
source Publicly Available Content Database; PubMed Central
subjects Abdomen
Adipose tissue
Adult
Asian Americans
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Blood plasma
Blood pressure
Body mass index
Ceramide
Chromatography
Development and progression
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetics
Endocrinology
Glucose
Health aspects
Health risks
Hemoglobin
Hip
Humans
Hypertension
Incidence
Insulin resistance
Lecithin
Lipids
Lipids - blood
Liquid chromatography
Liver
Male
Mass spectrometry
Mass spectroscopy
Medical research
Medicine
Medicine and Health Sciences
Metabolic syndrome
Metabolism
Metabolites
Middle Aged
Obesity
Obesity, Abdominal - blood
Obesity, Abdominal - physiopathology
Pharmaceutical sciences
Pharmacy
Phosphatidylcholine
Phospholipids
Physiology
Plant lipids
Prediabetic state
Prediabetic State - blood
Prediabetic State - epidemiology
Republic of Korea - epidemiology
Risk analysis
Risk Factors
Spectroscopy
Sphingolipids
Sphingomyelin
Sphingomyelins - blood
Type 2 diabetes
title Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T01%3A12%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20sphingomyelins%20increase%20in%20pre-diabetic%20Korean%20men%20with%20abdominal%20obesity&rft.jtitle=PloS%20one&rft.au=Im,%20Seung-Soon&rft.date=2019-03-05&rft.volume=14&rft.issue=3&rft.spage=e0213285&rft.pages=e0213285-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0213285&rft_dat=%3Cgale_plos_%3EA577131543%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c692t-76ca79aa1f7d6b6abbe7521b171792163e87b26aa35a7f6b804fd7c3b0d300b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2188347244&rft_id=info:pmid/30835753&rft_galeid=A577131543&rfr_iscdi=true