Neoadjuvant therapy for thymic neoplasms reduces tumor volume per 3D-reconstructed images but does not improve the complete resection rate

Complete resection of thymic neoplasms is important for achieving a favorable prognosis; however, the efficacy of neoadjuvant therapy remains controversial. We investigated the effect of induction therapy on complete resection and survival using 3-dimensionally reconstructed images to measure tumor...

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Bibliographic Details
Published in:PloS one 2019-03, Vol.14 (3), p.e0214291-e0214291
Main Authors: Suh, Jee Won, Park, Seong Yong, Lee, Chang Young, Song, Seung Hwan, Kim, Dae Joon, Paik, Hyo Chae, Chung, Kyoung Young, Hong, Min Hee, Kim, Hye Ryun, Cho, Byoung Chul, Lee, Jin Gu
Format: Article
Language:English
Subjects:
Adjuvant chemotherapy
Aged
Analysis
Cancer therapies
Care and treatment
Chemotherapy
Comparative analysis
Female
Heart surgery
Hospitals
Humans
Image reconstruction
Imaging, Three-Dimensional - methods
Induction therapy
Internal medicine
Kaplan-Meier Estimate
Male
Measurement methods
Medicine
Medicine and Health Sciences
Middle Aged
Neoadjuvant Therapy
Neoplasm Staging
Neoplasms
Oncology
Patients
Prognosis
Proportional Hazards Models
Recurrence
Retrospective Studies
Software
Subgroups
Surgery
Survival
Therapy
Thymus
Thymus Gland - diagnostic imaging
Thymus Neoplasms - mortality
Thymus Neoplasms - pathology
Thymus Neoplasms - surgery
Thymus Neoplasms - therapy
Tomography, X-Ray Computed
Tumors
University colleges
Vincristine
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Summary:Complete resection of thymic neoplasms is important for achieving a favorable prognosis; however, the efficacy of neoadjuvant therapy remains controversial. We investigated the effect of induction therapy on complete resection and survival using 3-dimensionally reconstructed images to measure tumor volume. Eighty-nine patients who underwent surgical resection for Masaoka-Koga stage III-IV thymic neoplasms between January 2000 and December 2013 were enrolled, including 71 and 18 in the primary surgery and neoadjuvant therapy groups, respectively. Baseline characteristics, postoperative outcomes, and survival rates were analyzed. Moreover, baseline and post-neoadjuvant therapy tumor volumes were compared among patients in the neoadjuvant group. Adjacent mediastinal structure invasion was significantly rarer in the primary surgery group than in the neoadjuvant group (1.27±1.09 vs. 2.61±1.42, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0214291