Mitochondrial genetic haplogroups and cardiovascular diseases: Data from the Osteoarthritis Initiative

• Published in: PloS one 2019-03, Vol.14 (3), p.e0213656-e0213656
• Main Authors: Veronese, Nicola, Stubbs, Brendon, Koyanagi, Ai, Vaona, Alberto, Demurtas, Jacopo, Schofield, Patricia, Maggi, Stefania
• Format: Article
• Language: English
• Subjects: Aged; Aging; Analysis; Arthritis; Biocompatibility; Biology and Life Sciences; Cardiomyopathy; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - genetics; Confidence intervals; Deoxyribonucleic acid; Diabetes; Diabetic retinopathy; DNA; DNA, Mitochondrial - genetics; Female; Follow-Up Studies; Gastroenterology; Genes, Mitochondrial; Genetic Predisposition to Disease; Genetic research; Genetics; Genomes; Haplotypes; Health aspects; Heart attacks; Heart diseases; Humans; Hypertension; Knee; Longitudinal Studies; Male; Medicine and Health Sciences; Middle Aged; Mitochondria; Mitochondrial diseases; Mitochondrial DNA; Mutation; Neurosciences; Nomenclature; Osteoarthritis; Osteoarthritis, Knee - genetics; Polymerase chain reaction; Polymorphism, Restriction Fragment Length; Population; Population (statistical); Primary care; Proportional Hazards Models; Prospective Studies; R&D; Regression analysis; Research & development; Research and Analysis Methods; Restriction fragment length polymorphism; Risk; Risk management; Risk reduction; Statistical analysis
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0213656

Some case-control studies reported that mitochondrial haplogroups could be associated with the onset of cardiovascular diseases (CVD), but the literature regarding this topic is limited. We aimed to investigate whether any mitochondrial haplogroup carried a higher or lower risk of CVD in a large cohort of North American people affected by knee osteoarthritis or at high risk for this condition. A longitudinal cohort study including individuals from the Osteoarthritis Initiative was done. Haplogroups were assigned through a combination of sequencing and PCR-RFLP techniques. All the mitochondrial haplogroups have been named following this nomenclature: HV, JT, UK, IWX, and superHV/others. The strength of the association between mitochondrial haplogroups and incident CVD was evaluated through a Cox's regression analysis, adjusted for potential confounders, and reported as hazard ratios (HRs) with their 95% confidence intervals (CIs). Overall, 3,288 Caucasian participants (56.8% women) with a mean age of 61.3±9.2 years without CVD at baseline were included. During a median follow-up of 8 years, 322 individuals (= 9.8% of baseline population) developed a CVD. After adjusting for 11 potential confounders at baseline and taking those with the HV haplotype as reference (the most frequent), those with JT carried a significant lower risk of CVD (HR = 0.75; 95%CI: 0.54-0.96; p = 0.03). Participants with the J haplogroup had the lowest risk of CVD (HR = 0.71; 95%CI: 0.46-0.95; p = 0.02). The presence of JT haplogroups (particularly J) may be associated with a reduced risk of CVD. However, this result was not based on a high level of statistical significance. Thus, future research with larger sample size is needed to assess whether our results can be corroborated.