A new model for lipid monolayer and bilayers based on thermodynamics of irreversible processes

Lipid monolayers are used as experimental model systems to study the physical chemical properties of biomembranes. With this purpose, surface pressure/area per molecule isotherms provide a way to obtain information on packing and compressibility properties of the lipids. These isotherms have been in...

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Bibliographic Details
Published in:PloS one 2019-04, Vol.14 (4), p.e0212269
Main Authors: Pinto, O A, Disalvo, E A
Format: Article
Language:English
Subjects:
Biological effects
Biology and Life Sciences
Biophysics
Chemical properties
Compressibility
Compression
Earth Sciences
Electrolytes
Fluxes
Formalism
Formalism (Literary criticism)
Gases
Hydration
Irreversible processes
Irreversible processes (Thermodynamics)
Isotherms
Kinetics
Lipid Bilayers - chemistry
Lipid membranes
Lipid monolayers
Lipids
Lipids - chemistry
Liposomes - chemistry
Membranes
Membranes - chemistry
Models, Theoretical
Monolayers
Novels
Organic chemistry
Osmosis - physiology
Phase transitions
Phospholipids
Physical Sciences
Pressure
Surface pressure
Surface Properties
Thermodynamics
Water
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Summary:Lipid monolayers are used as experimental model systems to study the physical chemical properties of biomembranes. With this purpose, surface pressure/area per molecule isotherms provide a way to obtain information on packing and compressibility properties of the lipids. These isotherms have been interpreted considering the monolayer as a two dimensional ideal or van der Waals gas without contact with the water phase. These modelistic approaches do not fit the experimental results. Based on Thermodynamics of Irreversible Processes (TIP), the expansion/compression process is interpreted in terms of coupled phenomena between area changes and water fluxes between a bidimensional solution of hydrated head groups in the monolayer and the bulk solution. The formalism obtained can reproduce satisfactorily the surface pressure/area per lipid isotherms of monolayer in different states and also can explain the area expansion and compression produced in particles enclosed by bilayers during osmotic fluxes. This novel approach gives relevance to the lipid-water interaction in restricted media near the membrane and provides a formalism to understand the thermodynamic and kinetic response of biointerphases to biological effectors.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0212269