Differential expression of senescence tumour markers and its implications on survival outcomes of breast cancer patients

Breast cancer is a heterogeneous disease displaying different histopathological characteristics, molecular profiling and clinical behavior. This study describes the expression patterns of senescence markers P53, DEC1 and DCR2 and assesses their significance on patient survival as a single or combine...

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Bibliographic Details
Published in:PloS one 2019-04, Vol.14 (4), p.e0214604-e0214604
Main Authors: Pare, Rahmawati, Soon, Patsy S, Shah, Aashit, Lee, Cheok Soon
Format: Article
Language:English
Subjects:
Aged
Apoptosis
Benign
Biomarkers
Biomarkers, Tumor - metabolism
Breast cancer
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Cancer
Cancer patients
Cancer therapies
Carcinoma
Cell cycle
Cell growth
Cell survival
Chemotherapy
Composition
Correlation
Criminal investigation
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
Diagnosis
Disease-Free Survival
Ductal carcinoma in situ
ErbB-2 protein
Estrogens
Female
Gene expression
Genes
Health aspects
Hormones
Hospitals
Humans
Hyperplasia
Immunohistochemistry
Invasiveness
Kaplan-Meier Estimate
Ligands
Markers
Medical prognosis
Medical research
Medicine
Middle Aged
Mutation
Neoplasm Recurrence, Local
Neoplasm Staging
p53 Protein
Pathology
Patient outcomes
Patients
Phenols (Class of compounds)
Phenotypes
Progesterone
Proportional Hazards Models
Proteins
Public relations executives
Receptor, ErbB-2 - metabolism
Receptors
Regression analysis
Retrospective Studies
Senescence
Sex hormones
Statistical analysis
Statistical tests
Surgery
Survival
Tissues
Tumor Necrosis Factor Decoy Receptors - metabolism
Tumor necrosis factor-TNF
Tumor proteins
Tumor Suppressor Protein p53 - metabolism
Tumor Suppressor Proteins - metabolism
Tumors
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Summary:Breast cancer is a heterogeneous disease displaying different histopathological characteristics, molecular profiling and clinical behavior. This study describes the expression patterns of senescence markers P53, DEC1 and DCR2 and assesses their significance on patient survival as a single or combined marker with P16 or P14 using breast cancer progression series. One thousand and eighty (1080) patients with primary invasive ductal carcinoma, no special type, were recruited through an 11-year retrospective study period. We constructed tissue microarrays of normal, benign hyperplasia, ductal carcinoma in situ and invasive ductal carcinoma from each patient and performed immunohistochemical staining to study the protein expression. Statistical analysis includes Pearson chi-square, Kaplan-Meier log ran test and Cox proportional hazard regression were undertaken to determine the associations and predict the survival outcomes. P53, DEC1 and DCR2 expression correlated significantly with normal, benign, premalignant and malignant tissues with (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0214604