Mood configurations and their relationship to immune system responses: Exploring the relationship between moods, immune system responses, thyroid hormones, and social support

Analyzing data on 2,057 healthy subjects in the Dutch Lifelines database we explore the relationship between immune system responses, thyroid hormone functioning and people's mood that is expected to be moderated by social support. We focus (1) on the innate immune system cell count: monocytes,...

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Published in:PloS one 2019-05, Vol.14 (5), p.e0216232
Main Authors: Masih, Jolly, Belschak, Frank, Verbeke, J M I Willem
Format: Article
Language:English
Subjects:
Adaptive Immunity
Adaptive systems
Adolescent
Adult
Affect
Aged
Biology and Life Sciences
Databases, Factual
Emotions
Female
Hormones
Humans
Immune system
Immune System Phenomena
Immunity, Innate
Innate immunity
Leukocytes (eosinophilic)
Leukocytes (granulocytic)
Lymphocytes
Lymphocytes - cytology
Lymphocytes - immunology
Lymphocytes - physiology
Lymphocytes B
Lymphocytes T
Male
Medicine and Health Sciences
Mental depression
Middle Aged
Monocytes
Mood
Moods
Natural killer cells
Netherlands
Philosophy
Platelets
Social interactions
Social Sciences
Social Support
Systematic review
Thrombocytes
Thyroid
Thyroid gland
Thyroid hormones
Thyroid Hormones - analysis
Thyroxine
Triiodothyronine
Young Adult
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description Analyzing data on 2,057 healthy subjects in the Dutch Lifelines database we explore the relationship between immune system responses, thyroid hormone functioning and people's mood that is expected to be moderated by social support. We focus (1) on the innate immune system cell count: monocytes, eosinophil granulocytes, basophilic granulocytes, neutrophil granulocytes; and thrombocytes; and (2) on the adaptive immune system cell count: lymphocytes (T, B and NK cells). Moods were measured on the positive (PA) and negative (NA) dimensions of the PANAS scale, divided in four groups based on their PA and NA median scores: hedonic, positive mood, negative mood and anhedonic. We focus further on (3) thyroid cells: T3 and T4; and (4) on social support. We found significant differences between mood groups and mean cell counts for basophilic granulocytes and thrombocytes but not for monocytes, eosinophil granulocytes and neutrophil granulocytes in the innate immune system. However, in the adaptive immune system we found mean lymphocyte cell counts to be different in all four mood groups. We also found that T3 and T4 levels differ significantly across all mood groups and work in very close association with lymphocytes to activate the adaptive immune system. These differences were most significant in the hedonic and anhedonic groups. The findings allow us to better understand mood groups, especially the hedonic and anhedonic groups, and open up new avenues for intervention.
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subjects Adaptive Immunity
Adaptive systems
Adolescent
Adult
Affect
Aged
Biology and Life Sciences
Databases, Factual
Emotions
Female
Hormones
Humans
Immune system
Immune System Phenomena
Immunity, Innate
Innate immunity
Leukocytes (eosinophilic)
Leukocytes (granulocytic)
Lymphocytes
Lymphocytes - cytology
Lymphocytes - immunology
Lymphocytes - physiology
Lymphocytes B
Lymphocytes T
Male
Medicine and Health Sciences
Mental depression
Middle Aged
Monocytes
Mood
Moods
Natural killer cells
Netherlands
Philosophy
Platelets
Social interactions
Social Sciences
Social Support
Systematic review
Thrombocytes
Thyroid
Thyroid gland
Thyroid hormones
Thyroid Hormones - analysis
Thyroxine
Triiodothyronine
Young Adult
title Mood configurations and their relationship to immune system responses: Exploring the relationship between moods, immune system responses, thyroid hormones, and social support
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