Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system

To describe the epidemiology of holoprosencephaly (HPE) in China with special reference to prevalence and associated anomalies. Data were abstracted from the Chinese Birth Defects Monitoring Network for the period 2007-2014. Birth prevalence of HPE were assessed by birth year, fetal/infant sex, mate...

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Bibliographic Details
Published in:PloS one 2019-06, Vol.14 (6), p.e0217835-e0217835
Main Authors: Yi, Ling, Liu, Zhongqiang, Deng, Changfei, Li, Xiaohong, Wang, Ke, Deng, Kui, Mu, Yi, Zhu, Jun, Li, Qi, Wang, Yanping, Dai, Li
Format: Article
Language:English
Subjects:
Adult
Age
Analysis
Anomalies
Biology and Life Sciences
Birth
Birth defects
Childbirth & labor
China - epidemiology
Cohort analysis
Confidence intervals
Congenital defects
Congenital diseases
Earth Sciences
Education
Epidemiology
Female
Fetuses
Future predictions
Genetic counseling
Genetics
Holoprosencephaly
Holoprosencephaly - epidemiology
Hospitals
Humans
Infant, Newborn
Infants
Laboratories
Male
Medicine and Health Sciences
Metropolitan areas
Nervous system
Obstetrics
Pediatrics
People and Places
Population Surveillance
Prevalence studies (Epidemiology)
Prognosis
Public relations
Residential areas
Retrospective Studies
Risk factors
Statistical tests
Surveillance
Trends
Ultrasonic imaging
Urban areas
Womens health
Young Adult
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Summary:To describe the epidemiology of holoprosencephaly (HPE) in China with special reference to prevalence and associated anomalies. Data were abstracted from the Chinese Birth Defects Monitoring Network for the period 2007-2014. Birth prevalence of HPE were assessed by birth year, fetal/infant sex, maternal age, and maternal residential area. Poisson regressions were used to calculate the crude and adjusted prevalence ratios (PR) and their 95% confidence intervals, and linear chi-square test was used to explore time trend for the prevalence of HPE. A total of 1222 HPE cases were identified in 13,284,142 births, yielding an overall prevalence of 0.92 per 10,000 births. The annual prevalence of HPE presented an upward trend (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0217835