A transcriptional signature associated with non-Hodgkin lymphoma in the blood of patients with Q fever

Coxiella burnetii, the agent causing Q fever, has been associated with B-cell non-Hodgkin lymphoma (NHL). To better clarify this link, we analysed the genetic transcriptomic profile of peripheral blood leukocytes from patients with C. burnetii infection to identify possible links to lymphoma. Microa...

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Bibliographic Details
Published in:PloS one 2019-06, Vol.14 (6), p.e0217542-e0217542
Main Authors: Melenotte, Cléa, Mezouar, Soraya, Ben Amara, Amira, Benatti, Simon, Chiaroni, Jacques, Devaux, Christian, Costello, Régis, Kroemer, Guido, Mege, Jean-Louis, Raoult, Didier
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - genetics
Bacterial infections
Biochemistry, Molecular Biology
Biology and Life Sciences
Blood
Cancer
Cell growth
Chlamydia
Coxiella burnetii - pathogenicity
DNA microarrays
Ets-1 protein
Female
Fever
Gene expression
Gene Expression Profiling - methods
Genes
Genetic analysis
Genetic aspects
Genetic research
Genetic transcription
Genomics
Health risk assessment
Hematology
Hepatitis
Hodgkin's disease
Human health and pathology
Humans
Infections
Infectious diseases
Leukemia
Leukocytes
Leukocytes, Mononuclear - metabolism
Leukocytes, Mononuclear - microbiology
Life Sciences
Lymphadenitis
Lymphadenitis - genetics
Lymphadenitis - microbiology
Lymphocytes B
Lymphoma
Lymphoma, Non-Hodgkin - genetics
Lymphoma, Non-Hodgkin - metabolism
Lymphoma, Non-Hodgkin - microbiology
Male
Medicin och hälsovetenskap
Medicine and Health Sciences
Microarray Analysis
Middle Aged
Non-Hodgkin's lymphoma
Non-Hodgkin's lymphomas
Peripheral blood
Persistent infection
Pneumonia
Proteins
Q fever
Q Fever - genetics
Q Fever - microbiology
Research and Analysis Methods
Risk factors
Transcription
Transcription, Genetic - genetics
Up-Regulation - genetics
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Summary:Coxiella burnetii, the agent causing Q fever, has been associated with B-cell non-Hodgkin lymphoma (NHL). To better clarify this link, we analysed the genetic transcriptomic profile of peripheral blood leukocytes from patients with C. burnetii infection to identify possible links to lymphoma. Microarray analyses revealed that 1189 genes were expressed differently (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0217542