Evaluation of cerebrovascular reactivity in chronic hepatitis C patients using transcranial color Doppler

Hepatitis C viral (HCV) infection is associated with systemic inflammation and metabolic complications that might predispose patients to atherosclerosis, including cerebrovascular atherosclerosis. The aim of this study was to assess cerebrovascular reactivity in patients with chronic hepatitis C. Se...

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Published in:PloS one 2019-06, Vol.14 (6), p.e0218206-e0218206
Main Authors: Pavicic Ivelja, Mirela, Ivic, Ivo, Dolic, Kresimir, Mestrovic, Antonio, Perkovic, Nikola, Jankovic, Stipan
Format: Article
Language:English
Subjects:
Adult
Alcohol
Alcohol use
Arteriosclerosis
Atherosclerosis
Biology and life sciences
Blood
Blood & organ donations
Blood diseases
Blood donation
Blood flow
Blood Flow Velocity
Cardiovascular disease
Cerebrovascular Circulation
Cerebrovascular diseases
Cerebrovascular disorders
Chronic infection
Color
Complications
Complications and side effects
Diabetes
Doppler ultrasonography
Female
Flow velocity
Gastroenterology
Health risks
Hemodynamics
Hepatitis
Hepatitis C
Hepatitis C virus
Hepatitis C, Chronic - diagnostic imaging
Hepatitis C, Chronic - physiopathology
Hepatology
Hospitals
Humans
Hypertension
Infection
Infections
Infectious diseases
Inflammation
Liver diseases
Male
Medical research
Medicine and health sciences
Metabolism
Methods
Middle Aged
Reactivity
Risk factors
Sociodemographics
Statistical analysis
Stroke
Studies
Systematic review
Ultrasonic imaging
Ultrasonography, Doppler, Transcranial
Vascular diseases
Veins & arteries
Velocity
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cited_by cdi_FETCH-LOGICAL-c692t-1740e38325f0fdc998fbf2293172d49779d083dd9e0aee874857cd5e536fd86e3
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creator Pavicic Ivelja, Mirela
Ivic, Ivo
Dolic, Kresimir
Mestrovic, Antonio
Perkovic, Nikola
Jankovic, Stipan
description Hepatitis C viral (HCV) infection is associated with systemic inflammation and metabolic complications that might predispose patients to atherosclerosis, including cerebrovascular atherosclerosis. The aim of this study was to assess cerebrovascular reactivity in patients with chronic hepatitis C. Seventeen patients with chronic hepatitis C infection, as well as 11 healthy blood donors in the control group, were assessed for cerebrovascular reactivity according to the well-established breath-holding test that uses the transcranial color Doppler for measurement of blood flow velocity. Results obtained during the breath-holding revealed significantly lower average peak systolic (AvPS start, P = 0.018), end-diastolic (AvED start, P = 0.031) and mean velocity values at the very beginning of the breath-holding procedure (AvmeanV start, P = 0.02), as well as a lower mean peak systolic velocity at the end of the breath-holding test (AvPS max, P = 0.02) in the hepatitis C group. Vascular reactivity values, calculated as the breath-holding index, were also significantly lower (P = 0.045) in the hepatitis C group. In conclusion, the results of this study suggest an association between chronic HCV infection and altered cerebrovascular reactivity which may ultimately have an unfavorable effect on cerebrovascular hemodynamics and lead to increased risk of cerebrovascular diseases.
doi_str_mv 10.1371/journal.pone.0218206
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The aim of this study was to assess cerebrovascular reactivity in patients with chronic hepatitis C. Seventeen patients with chronic hepatitis C infection, as well as 11 healthy blood donors in the control group, were assessed for cerebrovascular reactivity according to the well-established breath-holding test that uses the transcranial color Doppler for measurement of blood flow velocity. Results obtained during the breath-holding revealed significantly lower average peak systolic (AvPS start, P = 0.018), end-diastolic (AvED start, P = 0.031) and mean velocity values at the very beginning of the breath-holding procedure (AvmeanV start, P = 0.02), as well as a lower mean peak systolic velocity at the end of the breath-holding test (AvPS max, P = 0.02) in the hepatitis C group. Vascular reactivity values, calculated as the breath-holding index, were also significantly lower (P = 0.045) in the hepatitis C group. 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The aim of this study was to assess cerebrovascular reactivity in patients with chronic hepatitis C. Seventeen patients with chronic hepatitis C infection, as well as 11 healthy blood donors in the control group, were assessed for cerebrovascular reactivity according to the well-established breath-holding test that uses the transcranial color Doppler for measurement of blood flow velocity. Results obtained during the breath-holding revealed significantly lower average peak systolic (AvPS start, P = 0.018), end-diastolic (AvED start, P = 0.031) and mean velocity values at the very beginning of the breath-holding procedure (AvmeanV start, P = 0.02), as well as a lower mean peak systolic velocity at the end of the breath-holding test (AvPS max, P = 0.02) in the hepatitis C group. Vascular reactivity values, calculated as the breath-holding index, were also significantly lower (P = 0.045) in the hepatitis C group. In conclusion, the results of this study suggest an association between chronic HCV infection and altered cerebrovascular reactivity which may ultimately have an unfavorable effect on cerebrovascular hemodynamics and lead to increased risk of cerebrovascular diseases.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>31185040</pmid><doi>10.1371/journal.pone.0218206</doi><tpages>e0218206</tpages><orcidid>https://orcid.org/0000-0002-8878-7164</orcidid><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
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1932-6203
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source PubMed (Medline); Publicly Available Content Database
subjects Adult
Alcohol
Alcohol use
Arteriosclerosis
Atherosclerosis
Biology and life sciences
Blood
Blood & organ donations
Blood diseases
Blood donation
Blood flow
Blood Flow Velocity
Cardiovascular disease
Cerebrovascular Circulation
Cerebrovascular diseases
Cerebrovascular disorders
Chronic infection
Color
Complications
Complications and side effects
Diabetes
Doppler ultrasonography
Female
Flow velocity
Gastroenterology
Health risks
Hemodynamics
Hepatitis
Hepatitis C
Hepatitis C virus
Hepatitis C, Chronic - diagnostic imaging
Hepatitis C, Chronic - physiopathology
Hepatology
Hospitals
Humans
Hypertension
Infection
Infections
Infectious diseases
Inflammation
Liver diseases
Male
Medical research
Medicine and health sciences
Metabolism
Methods
Middle Aged
Reactivity
Risk factors
Sociodemographics
Statistical analysis
Stroke
Studies
Systematic review
Ultrasonic imaging
Ultrasonography, Doppler, Transcranial
Vascular diseases
Veins & arteries
Velocity
title Evaluation of cerebrovascular reactivity in chronic hepatitis C patients using transcranial color Doppler
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