Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection

CircRNAs are involved in a variety of human diseases, however, the expression profiles and the potential diagnostic value of circRNAs in human acute Stanford type A aortic dissection (AAAD) remains largely unknown. In this study, high-throughput RNA sequencing (RNA-Seq) was used to investigate the d...

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Bibliographic Details
Published in:PloS one 2019-06, Vol.14 (6), p.e0219013-e0219013
Main Authors: Tian, Congcong, Tang, Xinlong, Zhu, Xiyu, Zhou, Qing, Guo, Yuting, Zhao, Rui, Wang, Dongjin, Gong, Bing
Format: Article
Language:English
Subjects:
Adult
Aged
Aneurysm, Dissecting - blood
Aneurysm, Dissecting - diagnosis
Aneurysms
Aorta
Aortic dissection
Apoptosis
Binding sites
Biological markers
Biology and life sciences
Biomarkers
Biomarkers - blood
Cell growth
Correlation analysis
Diagnostic systems
Dissection
Female
Gene expression
Gene Expression Profiling
Gene sequencing
Genes
Genetic aspects
Growth factors
Heart surgery
High-Throughput Nucleotide Sequencing
Hospitals
Humans
Hypertension
Kinases
Laboratories
Male
Medical diagnosis
Medical schools
Medicine and Health Sciences
Messenger RNA
MicroRNA
Middle Aged
miRNA
Mortality
mRNA
Network analysis
Phenols (Class of compounds)
Protein kinase
Protein kinases
Proteins
Research and analysis methods
Ribonucleic acid
RNA
RNA sequencing
RNA, Circular - blood
RNA, Circular - genetics
Sequence Analysis, RNA
Smooth muscle
Studies
Surgery
Tyrosine
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Summary:CircRNAs are involved in a variety of human diseases, however, the expression profiles and the potential diagnostic value of circRNAs in human acute Stanford type A aortic dissection (AAAD) remains largely unknown. In this study, high-throughput RNA sequencing (RNA-Seq) was used to investigate the differentially expressed circRNAs, microRNAs (miRs) and mRNAs in human AAAD tissues (n = 10) compared with normal aortic tissues (n = 10). The results of RNA-Seq revealed that 506 circRNAs were significantly dysregulated (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0219013