More diversity in epithelial cell polarity: A fruit flies' gut feeling

Multicellular animals face the principle challenge to deal with two distinct compartments: the internal organismal compartment and the external environment. This challenge is met by the differentiation of cell sheets into epithelia, which provide a dynamic barrier in tissues, organs, and organisms....

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Bibliographic Details
Published in:PLoS biology 2018-12, Vol.16 (12), p.e3000082
Main Author: Müller, H-Arno J
Format: Article
Language:English
Subjects:
Animals
Biology and Life Sciences
Cell growth
Cell Polarity
Cysts
Diptera
Drosophila
Drosophila melanogaster
Drosophila Proteins
Epithelial Cells
Fruit flies
Insects
Kinases
Mammals
Medicine and Health Sciences
Molecular machines
Morphogenesis
Organs
Physiological aspects
Polarity
Primer
Proteins
Regulation
Research and Analysis Methods
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Summary:Multicellular animals face the principle challenge to deal with two distinct compartments: the internal organismal compartment and the external environment. This challenge is met by the differentiation of cell sheets into epithelia, which provide a dynamic barrier in tissues, organs, and organisms. Cell polarity is key to all functions of epithelia, and compromising polarity causes many severe diseases. Within the past 20 years, research on Drosophila melanogaster discovered a conserved molecular machinery that controls epithelial polarity. Recent findings suggest that the textbook Drosophila-based paradigm of the control of epithelial polarity may not be as universal as previously assumed.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3000082