Lateral hypothalamic neurotensin neurons promote arousal and hyperthermia

Sleep and wakefulness are greatly influenced by various physiological and psychological factors, but the neuronal elements responsible for organizing sleep-wake behavior in response to these factors are largely unknown. In this study, we report that a subset of neurons in the lateral hypothalamic ar...

Full description

Saved in:
Bibliographic Details
Published in:PLoS biology 2019-03, Vol.17 (3), p.e3000172-e3000172
Main Authors: Naganuma, Fumito, Kroeger, Daniel, Bandaru, Sathyajit S, Absi, Gianna, Madara, Joseph C, Vetrivelan, Ramalingam
Format: Article
Language:English
Subjects:
Animals
Arousal
Arousal (Physiology)
Behavior
Biology and Life Sciences
Body Temperature
Electrophoresis
Eye movements
Fever
Fever - metabolism
Genotyping Techniques
Health aspects
Hyperthermia
Hypothalamic Area, Lateral - metabolism
Hypothalamus
Hypothalamus (lateral)
Inhibition (psychology)
Locomotion - physiology
Locomotor activity
Male
Medicine and Health Sciences
Mice
Neural circuitry
Neurons
Neurons - metabolism
Neuropeptides
Neurotensin
Neurotensin - metabolism
NREM sleep
Observations
Physiological aspects
Physiological effects
Physiology
Psychological factors
Psychological stress
Rapid eye movement state
REM sleep
Research and Analysis Methods
Rodents
Roles
Sleep
Sleep (NREM)
Sleep (REM)
Sleep and wakefulness
Social Sciences
Stress (physiology)
Wakefulness
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sleep and wakefulness are greatly influenced by various physiological and psychological factors, but the neuronal elements responsible for organizing sleep-wake behavior in response to these factors are largely unknown. In this study, we report that a subset of neurons in the lateral hypothalamic area (LH) expressing the neuropeptide neurotensin (Nts) is critical for orchestrating sleep-wake responses to acute psychological and physiological challenges or stressors. We show that selective activation of NtsLH neurons with chemogenetic or optogenetic methods elicits rapid transitions from non-rapid eye movement (NREM) sleep to wakefulness and produces sustained arousal, higher locomotor activity (LMA), and hyperthermia, which are commonly observed after acute stress exposure. On the other hand, selective chemogenetic inhibition of NtsLH neurons attenuates the arousal, LMA, and body temperature (Tb) responses to a psychological stress (a novel environment) and augments the responses to a physiological stress (fasting).
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3000172