Cooperation of dual modes of cell motility promotes epithelial stress relaxation to accelerate wound healing

Collective cell migration in cohesive units is vital for tissue morphogenesis, wound repair, and immune response. While the fundamental driving forces for collective cell motion stem from contractile and protrusive activities of individual cells, it remains unknown how their balance is optimized to...

Full description

Saved in:
Bibliographic Details
Published in:PLoS computational biology 2018-10, Vol.14 (10), p.e1006502-e1006502
Main Authors: Staddon, Michael F, Bi, Dapeng, Tabatabai, A Pasha, Ajeti, Visar, Murrell, Michael P, Banerjee, Shiladitya
Format: Article
Language:English
Subjects:
Actomyosin
Biology
Biology and Life Sciences
Biomedical engineering
Cell adhesion & migration
Cell division
Cell migration
Computer applications
Contractility
Fluidity
Genetic transformation
Immune response
Immune system
Kinetics
Mechanical properties
Mechanics
Medicine and Health Sciences
Morphogenesis
Morphology
Motility
Physical Sciences
Physics
Repair
Software
Stochasticity
Stress relaxation
Substrates
Tissues
Transformation
University colleges
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Collective cell migration in cohesive units is vital for tissue morphogenesis, wound repair, and immune response. While the fundamental driving forces for collective cell motion stem from contractile and protrusive activities of individual cells, it remains unknown how their balance is optimized to maintain tissue cohesiveness and the fluidity for motion. Here we present a cell-based computational model for collective cell migration during wound healing that incorporates mechanochemical coupling of cell motion and adhesion kinetics with stochastic transformation of active motility forces. We show that a balance of protrusive motility and actomyosin contractility is optimized for accelerating the rate of wound repair, which is robust to variations in cell and substrate mechanical properties. This balance underlies rapid collective cell motion during wound healing, resulting from a tradeoff between tension mediated collective cell guidance and active stress relaxation in the tissue.
ISSN:1553-7358
1553-734X
1553-7358
DOI:10.1371/journal.pcbi.1006502